February 2023 in “Global journal of health sciences and research” This study found no association between serum zinc levels and alopecia areata severity in patients.
11 citations
,
February 2019 in “Journal of Cosmetic Dermatology” This study found that male androgenetic alopecia patients had significantly lower serum zinc levels and suboptimal biotin levels compared to healthy controls, suggesting the potential value of zinc and biotin supplementation.
December 2009 in “DergiPark (Istanbul University)” This study found that low levels of ferritin and iron were common among women with diffuse hair loss, suggesting these tests could be useful in evaluating such patients.
21 citations
,
January 2014 in “Dermatology Research and Practice” This study found no significant difference in serum and hair levels of iron, zinc, and copper between female alopecia areata patients and healthy controls.
November 2025 in “Healthcare” This study found that individuals with hair loss complaints had slightly lower zinc levels compared to controls, but the difference was clinically insignificant, suggesting zinc testing is not essential for diagnosing hair loss.
6 citations
,
January 2018 in “PubMed” This study suggests that elevated levels of certain heavy metals, rather than zinc, may play a causative role in primary chronic telogen effluvium.
February 2021 in “Austin journal of nutrition & metabolism” This study found that among university students, both low and high zinc levels were associated with significant hair loss, while these zinc concentrations did not significantly impact other health issues like diarrhea, acne, or weight loss.
73 citations
,
January 2013 in “Annals of Dermatology” This study observed that patients with various types of hair loss had significantly lower serum zinc levels compared to healthy controls, suggesting zinc disturbance may play a role in the condition.
February 1990 in “Pathology, research and practice” This study in rats with a portocaval shunt observed severe ultrastructural damage to the inner ear, associated with zinc deficiency and symptoms resembling liver cirrhosis in humans.
In this case report, a two-year-old girl with acrodermatitis enteropathica was misdiagnosed for over a year before low serum zinc levels led to the correct diagnosis, and her skin lesions resolved completely after two weeks of zinc sulfate treatment.
17 citations
,
September 2000 in “Journal of dermatology” This case report describes a rare instance where a child with nonketotic hyperglycinemia developed an acrodermatitis enteropathica-like eruption, likely due to combined zinc and branched chain amino acid deficiencies.
March 2024 in “International journal of molecular sciences” This study suggests that abnormal levels of zinc, copper, and iron in serum or hair may serve as auxiliary and prognostic tests for various skin diseases, though further research is necessary due to conflicting data.
September 2025 in “Pakistan Journal of Science” This study observed that individuals with type 1 diabetes mellitus have notably lower levels of essential and trace elements like Calcium, Potassium, and Zinc in biological samples compared to non-diabetic controls.
63 citations
,
May 2017 in “American Journal of Clinical Dermatology” This review found that patients with alopecia areata may have lower levels of vitamin D, zinc, and folate, but conflicting evidence precludes definitive clinical recommendations for micronutrient supplementation.
35 citations
,
January 2006 in “Journal of Dermatological Treatment” This review found little evidence supporting zinc as a first-line treatment for dermatological conditions, except in cases of systemic zinc deficiency, and suggests further research is needed.
5 citations
,
December 2014 in “Polish Journal of Public Health” This review discusses the mechanisms of zinc transport, its role in human health, and the effects of zinc imbalance, without reporting new results.
3 citations
,
February 2005 in “Journal of Quantitative Spectroscopy & Radiative Transfer/Journal of quantitative spectroscopy & radiative transfer” This study found that hair content of iron and zinc does not play a role in chemotherapy-induced alopecia in children with cancer.
August 2023 in “Dermatology reports” This case study of a 2-month-old boy with maple syrup urine disease highlights the dangers of restricting branched-chain amino acid intake, as it led to acrodermatitis dysmetabolica-like skin eruptions and hair loss, later resolved with careful dietary adjustments and monitoring.
January 2026 in “Journal of Trace Elements in Medicine and Biology” This study found that living environment significantly influenced Fe concentrations in dog and cat hair, with outdoor animals showing higher levels than those kept indoors.
246 citations
,
April 1976 in “Annals of Surgery” In this study, a syndrome of zinc deficiency was observed in adults receiving intravenous feeding, with zinc supplementation improving symptoms except for delayed hair regrowth.
November 2023 in “Biology” This study investigated 130 patients and found a significant inverse correlation between copper content and the copper/zinc ratio in hair samples and the extent of coronary artery disease, while zinc content alone showed no significant relationship with disease extent.
65 citations
,
August 2016 in “Metabolic brain disease” This study found that children with autism spectrum disorder generally have lower levels of both essential and toxic trace elements in their hair compared to controls.
15 citations
,
July 2012 in “Biological trace element research” This study found that an increased calcium/magnesium ratio in hair and lower chromium concentration were associated with higher insulin resistance in Korean adult males.
11 citations
,
March 2023 in “Frontiers in Nutrition” This study found that a modest increase in dietary zinc over six months resulted in a detectable increase in sulfur and zinc counts in individual hairs, suggesting a non-invasive method to monitor zinc intake effects.
4 citations
,
January 2023 in “Frontiers in Medicine” This review discusses the use of zinc supplementation in dermatology for various skin conditions and reports no new clinical results, providing references for its application.
14 citations
,
January 2016 in “International Journal of Trichology” This study observed that many female pattern hair loss patients had concurrent conditions such as telogen effluvium, hypothyroidism, and hypertension, with a significant percentage having low Vitamin D levels.
134 citations
,
December 2018 in “Dermatology and Therapy” This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.
7 citations
,
January 2002 in “Biological Trace Element Research” This study found that children with pituitary dwarfism had higher zinc and copper hair concentrations and lower manganese concentrations compared to healthy children.
1 citations
,
June 2007 in “Almustansiriya journal of pharmaceutical sciences/Al-Mustansiriyah journal of pharmaceutical sciences” This study found that a two-month antioxidant treatment significantly improved hair growth in patients with alopecia areata by enhancing antioxidant defenses and correcting trace metal imbalances.
March 2011 in “Journal of clinical and experimental investigations” This study describes two thallium poisoning outbreaks, highlighting characteristic symptoms like hair loss and peripheral neuropathy, and emphasizes that such poisoning can stem from accidental or criminal ingestion.