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The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Androgens can both increase and decrease hair growth in different parts of the body.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Androgens can cause hair growth in some areas and hair loss on the scalp.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Liposomes improve drug delivery and reduce skin irritation in dermatology.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

IL-2 treatment causes skin eruptions and other reversible side effects, and may play a role in psoriasis.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

The Protein-Sparing Modified Fast is effective for rapid weight loss and maintaining it, but requires medical supervision and can have side effects.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.

A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

Effective hair loss treatment in women requires correct diagnosis and can include medications like minoxidil, antiandrogens, and treatments for underlying conditions like PCOS.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

Fat tissue cells are a promising option for healing various diseases, but more research is needed to ensure they are safe and effective.

Zinc deficiency in children can cause skin issues and can be serious if not diagnosed and treated properly.

Biotin treatment can significantly improve hair loss and motor functions in certain metabolic disorders.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.