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GlossaryUnsaturated Fatty Acids

contain one or more double bonds in their hydrocarbon chains

Unsaturated fatty acids (UFAs) are a type of fat molecule that contains one or more double bonds between carbon atoms in their hydrocarbon chain. These double bonds create kinks in the chain, preventing the molecules from packing tightly together, which is why unsaturated fats are typically liquid at room temperature. They are considered healthier than saturated fats and are found in foods like olive oil, nuts, and fish.

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Transfollicular Enhancement of Gel Containing Cationic Niosomes Loaded with Unsaturated Fatty Acids in Rice Bran Semi-Purified Fraction

research Transfollicular Enhancement of Gel Containing Cationic Niosomes Loaded with Unsaturated Fatty Acids in Rice Bran Semi-Purified Fraction

21 citations, April 2012 in “European Journal of Pharmaceutics and Biopharmaceutics”

The gel with special fat-loaded particles from rice bran could be an effective skin treatment for hair loss.

research Distribution of Glycolipid and Unsaturated Fatty Acids in Human Hair

18 citations, August 2014 in “Lipids”

Human hair has more unsaturated fats inside than on the surface, and certain lipids may help bind the outer and inner layers together.

research Omega-6 Highly Unsaturated Fatty Acids in Leydig Cells Facilitate Male Sex Hormone Production

7 citations, September 2022 in “Communications biology”

Omega-6 fats in certain cells boost male hormone production.

research The Fatty Acids and the Skin: A Focus on the N-6 Family of Unsaturated Fatty Acids

1 citations, January 2012 in “Human health handbooks”

Linoleic acid is important for healthy skin, and while most people get enough from their diet, not having enough can cause skin and hair problems.

research The Fatty Acids and the Skin: A Focus on the N-6 Family of Unsaturated Fatty Acids

November 2012

Linoleic acid is essential for healthy skin, and while deficiency is rare in Western societies, it can cause dry, scaly skin and hair loss.

research Effect of Hair Oils and Fatty Acids on the Growth of Dermatophytes and Their In Vitro Penetration of Human Scalp Hair

4 citations, November 1970 in “PubMed”

Mustard oil and unsaturated fatty acids can stop the growth of scalp fungus and prevent it from infecting hair.

research Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia

14 citations, October 2018 in “PloS one”

Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.

research Optimization of Bear Oil Extraction Process and Hair Growth Activity

March 2024 in “Molecules/Molecules online/Molecules annual”

Enzymatically extracted bear oil has more unsaturated fats and significantly increases hair growth in mice.

research The Role of Sebaceous Gland Activity and Scalp Microfloral Metabolism in the Etiology of Seborrheic Dermatitis and Dandruff

241 citations, August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Dandruff and seborrheic dermatitis are caused by yeast feeding on scalp oils, leading to irritation and flaking.

Phytochemical Analyses of Ziziphus Jujuba Mill. Var. Spinosa Seed by Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry and Gas Chromatography-Mass Spectrometry

research Phytochemical Analyses of Ziziphus Jujuba Mill. Var. Spinosa Seed by Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry and Gas Chromatography-Mass Spectrometry

38 citations, January 2013 in “Analyst”

The study found that Ziziphus jujuba seeds contain beneficial compounds for treating insomnia and anxiety and that the methods used are effective for assessing their quality.

research 5α-Reductase Type 1 Inhibition of Oryza Sativa Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

22 citations, August 2011 in “Journal of Supercritical Fluids”

Rice bran extract might help prevent hair loss.

research Red Ginseng (Panax Ginseng Meyer) Oil: A Comprehensive Review of Extraction Technologies, Chemical Composition, Health Benefits, Molecular Mechanisms, and Safety

11 citations, December 2021 in “Journal of Ginseng Research/Journal of ginseng research”

Red ginseng oil is believed to have various health benefits and is safe, but more research is needed to fully understand how it works.

research From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

July 2023 in “Plants”

Plant-based compounds can improve wound dressings and skin medication delivery.

research Building a Functional Niche for Hair Follicle Stem Cells

April 2017 in “Journal of Investigative Dermatology”

Deleting the CRIF1 gene in mice disrupts skin and hair formation, certain proteins affect hair growth, a new compound may improve skin and hair health, blood cell-derived stem cells can create skin-like structures, and hair follicle stem cells come from embryonic cells needing specific signals for development.

research Therapy of Alopecia: Psychological Impact and Treatments

January 2005 in “Farmaceutski glasnik”

Minoxidil and finasteride are key treatments for hair loss.

Human Hair Follicle Regeneration With Trichogenic Human Dermal Papilla Precursor Cells Derived From Induced Pluripotent Stem Cells

research Human Hair Follicle Regeneration With Trichogenic Human Dermal Papilla Precursor Cells Derived From Induced Pluripotent Stem Cells

April 2017 in “Journal of Investigative Dermatology”

Stem cells can create hair follicles, potentially treating permanent hair loss, and healthy skin and hair depend on mitochondrial function and special fats.

research Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry

71 citations, January 2014 in “Journal of Proteome Research”

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

research Sphingolipids of the Murine Hair

1 citations, January 2012 in “Journal of The Society of Japanese Women Scientists”

Murine hair has specific types of ceramides and glucosylceramides but lacks acylceramides.

research Penetration of Oils into Hair

June 2024 in “International Journal of Cosmetic Science”

Plant oils like coconut, camellia, and safflower can penetrate hair, making it stronger and softer.

research National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2

391 citations, November 2015 in “Journal of Clinical Lipidology”

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.

research Fatty Acids and Related Lipid Mediators in the Regulation of Cutaneous Inflammation

28 citations, January 2018 in “Biochemical Society Transactions”

Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.

ERK1/2 Pathway Involvement in Enhancement of Fatty Acids from Phaeodactylum Tricornutum Extract on Hair Follicle Cell Proliferation

research ERK1/2 Pathway Involvement in Enhancement of Fatty Acids from Phaeodactylum Tricornutum Extract on Hair Follicle Cell Proliferation

2 citations, October 2020 in “BioMed Research International”

Phaeodactylum tricornutum extract helps hair follicle cells grow by activating the ERK1/2 pathway.

research Evaluation of the Topical Use of Essential Fatty Acids in Rabbits with Skin Disorders

January 2021 in “Research journal for veterinary practitioners”

The document does not determine if essential fatty acids improve rabbit skin health.

GC-MS Profiling and In Silico Prediction of MAPK Receptor Activation by Fatty Acids of Watercress Oil for Hair Growth Marketed in Saudi Arabia

research GC-MS Profiling and In Silico Prediction of MAPK Receptor Activation by Fatty Acids of Watercress Oil for Hair Growth Marketed in Saudi Arabia

5 citations, January 2021 in “Journal of Saudi Chemical Society”

Watercress oil may promote hair growth by activating specific receptors.

research Efficacy of a Nutritional Supplement Standardized in Fatty Acids and Phytosterols on Hair Loss and Hair Health in Both Women and Men

3 citations, January 2017 in “Journal of cosmetology & trichology”

The nutritional supplement improved hair quality and reduced hair loss.

An Integrated Approach to Develop Innovative, Sustainable, and Effective Cosmetic Ingredients: The Case Report of Fatty Acids Enriched Wild Strawberry Waste Extract

research An Integrated Approach to Develop Innovative, Sustainable, and Effective Cosmetic Ingredients: The Case Report of Fatty Acids Enriched Wild Strawberry Waste Extract

November 2024 in “Applied Sciences”

Wild strawberry waste extract can be a sustainable cosmetic ingredient for treating acne and hair loss.

Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation

research Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation

19 citations, November 2018 in “Nutrients”

Annurca apple extract may protect mouse hair from damage by chemotherapy and could help treat hair loss without promoting cancer growth.

research Skinny Fat Cells Stimulate Wound Healing

9 citations, June 2020 in “Cell stem cell”

Skinny fat cells help wounds heal faster by releasing fatty acids.

research Micronutrients for Hair and Nails: A Review of Their Impact on Health

1 citations, January 2010 in “Springer eBooks”

Certain micronutrients may improve hair and nail health, but more research is needed to confirm their benefits.

research Maternal Western Diet Causes Inflammatory Milk and TLR2/4-Dependent Neonatal Toxicity

47 citations, June 2012 in “Genes & Development”

A mother's western diet can make her milk toxic, causing inflammation and hair loss in babies.