160 citations
,
January 2017 in “Development” This study found that hypertrophic chondrocytes at the fracture callus border may convert to osteoblasts, influenced by vasculature and pluripotency gene expression.
158 citations
,
August 2011 in “Reviews in endocrine and metabolic disorders” This review examines the functions of vitamin D and its receptor in skin and explores how these are regulated, reporting no new clinical results.
144 citations
,
September 2006 in “Clinics in Dermatology” This article outlines manifestations of systemic lupus erythematosus, noting rapid joint symptom improvement with corticosteroids and antimalarial drug responsiveness for skin symptoms, and links anti-Ro with photosensitive rash and subacute lupus.
139 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This article reviews androgenetic alopecia in women, highlighting diagnosis criteria and noting that topical minoxidil is currently the only proven treatment for hair growth; it reports no clinical trial findings.
137 citations
,
January 2000 in “Skin Pharmacology and Physiology” This review outlines the factors affecting skin greasiness and sebum production, highlighting measurement challenges but reports no new clinical findings; further research may guide sebosuppressive treatments for acne.
134 citations
,
January 2019 in “American journal of clinical dermatology” This review summarizes recent research on the skin microbiome's role in acne development and how antibiotic treatments affect skin microbes, but it reports no new clinical results.
134 citations
,
February 2005 in “Neuropsychopharmacology” GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.
132 citations
,
August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” This review discusses the roles of TGF-β family signaling in regulating normal and cancer stem cells and highlights the need for further research to develop potential cancer treatments; it reports no new results.
132 citations
,
July 2000 in “Lupus” This study found that chronic cutaneous lupus erythematosus with discoid lesions was the most common skin manifestation among patients with lupus erythematosus, while nonspecific skin lesions were linked to systemic lupus erythematosus, particularly during active disease phases.
113 citations
,
July 2015 in “Journal of Cosmetic Dermatology” This review discusses the cosmetic applications of platelet-rich plasma in dermatology, highlighting its potential benefits and the need for more controlled studies.
111 citations
,
November 2007 in “Clinics in Dermatology” This article discusses the histologic features of psoriasis, including psoriasiform epidermal hyperplasia and neutrophilic involvement, but reports no new clinical findings.
101 citations
,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports the successful differentiation of mouse induced pluripotent stem cells into keratinocytes that can regenerate skin and its structures in an in vivo environment.
100 citations
,
June 2002 in “Diabetologia” This study found that parents of women with PCOS have a higher prevalence of insulin resistance and Type II diabetes than parents of healthy women.
97 citations
,
February 2007 in “Clinical Obstetrics and Gynecology” This article reviews the diagnostic criteria and prevalence of PCOS, emphasizing its status as the most common endocrine disorder among women of reproductive age, with no new clinical results reported.
94 citations
,
September 2008 in “Journal of the American Academy of Dermatology” This study found that traction alopecia risk was higher in adults than children and increased further when traction was combined with chemically relaxed hair.
87 citations
,
October 1997 in “JAMA” This case series suggests a possible, though likely very rare, association between vaccinations and hair loss, calling for further research in more defined populations.
78 citations
,
December 2011 in “Clinical toxicology” This study describes a case series of nine patients experiencing symptoms of selenium toxicity after consuming a liquid dietary supplement with an excess amount of selenium.
75 citations
,
October 2010 in “Mammalian genome” In this study, specific genetic polymorphisms in the KRT71 gene were associated with hairless and curly phenotypes in Sphynx and Devon Rex cats.
75 citations
,
August 2018 in “Biochemical pharmacology” This review discusses the potential of targeting the endocannabinoid system for treating skin disorders and reports no new clinical results, highlighting the need for further research.
75 citations
,
November 2007 in “Clinical endocrinology” This study found that several drugs, including flutamide and spironolactone, significantly reduced hirsutism in women, with reduced effectiveness in those with higher BMI.
72 citations
,
April 2008 in “The Journal of urology/The journal of urology” This study found that 1-year use of 5alpha-reductase inhibitors, dutasteride or finasteride, significantly lowered dihydrotestosterone levels without adversely affecting bone density, lipids, or hemoglobin in normal men.
71 citations
,
February 2020 in “Journal of Translational Medicine” This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.
69 citations
,
January 2015 in “Current problems in dermatology” This review discusses trichoscopy as a noninvasive, effective technique for diagnosing various hair loss conditions and monitoring treatment, highlighting its potential to reduce scalp biopsy necessity.
68 citations
,
February 2019 in “Urology” Hormonal treatment in transgender women reduces semen quality, but stopping treatment may improve it.
67 citations
,
November 2002 in “Journal of The American Academy of Dermatology” This review discusses diagnostic approaches for women with diffuse, nonscarring hair loss and reports no new clinical results.
66 citations
,
June 2006 in “Journal of The American Academy of Dermatology” This study found that long-term finasteride treatment in men with androgenetic alopecia significantly increased hair weight and count compared to placebo over nearly four years.
63 citations
,
April 2018 in “Journal of the American Academy of Dermatology” This review discusses the efficacy and safety of topical JAK inhibitors for inflammatory skin conditions, reporting modest benefits in psoriasis and atopic dermatitis but mixed results for vitiligo and inconclusive data for alopecia areata.
63 citations
,
March 2011 in “Clinical Endocrinology” This review examines the evaluation and management of hirsutism and hyperandrogenism in postmenopausal women and reports no new clinical findings.
61 citations
,
January 2017 in “Human Reproduction Open” This review discusses hormone replacement therapy for women with premature ovarian insufficiency, strongly recommending it for symptom relief and bone protection, but notes a lack of evidence on optimal types and doses.
60 citations
,
September 2013 in “Alimentary Pharmacology & Therapeutics” This review discusses the dermatological adverse events from immunosuppressive and anti-TNF therapy in IBD, finding increased risks of non-melanoma skin cancer and other skin conditions, and recommends regular cancer screening.