August 2025 in “Scientific Reports” This study found that the protein C4BPA may link insulin resistance and acne vulgaris by influencing lipid metabolism and inflammatory pathways, suggesting it as a potential mediator in the pathogenesis of both conditions.
This study found that intrinsic feedback loops are crucial for maintaining the function of human dermal papilla cells during hair growth, highlighting the importance of autocrine signaling and niche reprogramming for advancing hair follicle biology and regenerative therapies for hair loss.
This study investigated dual TCR Treg cells in mouse tissues, revealing a high proportion and diverse pairing patterns compared to single TCR Tregs, providing insights into their origins and characteristics across different tissue locations.
In this study assessing post-menopausal Asian women, distinct shifts in Malassezia species prevalence on the skin were linked to increased inflammation and impaired skin barrier function, potentially driving disorders like psoriasis and seborrheic dermatitis.
In this study, researchers analyzed over 5,000 T cells per sample using scRNA+TCR-seq technology and found that dual TCR Tregs are present in high proportions across various mouse tissues, showing unique TCR pairing patterns, V(D)J usage, and mRNA expression compared to single TCR Tregs.
December 2024 in “Clinical Cosmetic and Investigational Dermatology” This study found that AA may have a protective role in the progression of both HBDC and CRC, suggesting potential new research avenues for treatments of these conditions.
August 2024 in “Qucosa (Saxon State and University Library Dresden)” In this study on mice, researchers observed that dermal white adipose tissue (dWAT) plays a key role in regulating skin inflammation and tissue repair; however, reduced expression of certain cytokines in obese mice may hinder these processes, indicating potential metabolic disruptions in dWAT during inflammation.
March 2024 in “Frontiers in genetics” This review discusses the insights gained from single-cell RNA sequencing of fibroblasts in various cancers and wound healing, highlighting differences in gene expression and novel interactions.
This study examined the molecular communication in psoriasis cells, highlighting unique immune cell interactions and identifying new features of the hair follicle cell-psoriasis axis. It suggests the potential for targeted therapies at the single-cell level to improve psoriasis treatment.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This research examined the transcriptional landscape of quiescent melanocyte stem cells (qMcSCs) in adult female mice, revealing significant heterogeneity within this cell population and identifying novel subpopulations that vary in immune privilege regulation, melanocyte differentiation potential, and neural crest potential.
January 2023 in “Åbo Akademi University Research Portal” This study found that vimentin is essential for proper wound healing and cell growth by influencing EMT signaling and mTOR activity in mice.
September 2022 in “Research Square (Research Square)” This study found that overexpressing Rps14 in supporting cells promoted hair cell regeneration in the organ of Corti by facilitating cell proliferation and differentiation.
July 2022 in “International journal of KIU” This article outlines the scope, publication standards, and authorship responsibilities of the International Journal of KIU, but reports no new research results.
This study identified a genetic locus associated with rhabdomyosarcoma susceptibility in mice and found that specific differentiation markers are linked to the regression of basal cell carcinoma.
In this study, botulinum toxin type A injections reduced the severity of treatment-resistant scalp psoriasis in more patients compared to placebo over a 12-week period.
January 2018 in “Online Publication Service of Würzburg University (Würzburg University)” This study found that donor age and culture medium significantly impact the quality of human full-thickness skin models, with implications for their use as animal model alternatives in research.
January 2017 in “Qucosa (Saxon State and University Library Dresden)” This study found that plasma protein binding significantly contributes to the shifts in glucocorticosteroid concentration ratios among blood, saliva, and hair, challenging prior assumptions about enzyme inactivation as the main factor.
March 2015 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This article discusses testosterone production in the human body and its effects on muscle mass, bone density, metabolism, and skin, but reports no new findings.
March 2013 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This review discusses the role of various hormones in diffuse hair loss and emphasizes the need for further research to clarify their complex interactions and potential therapeutic implications, but reports no new clinical results.
January 2012 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This article discusses the role of androgens in skin conditions like acne and alopecia, emphasizing combined systemic and topical therapy approaches, but it reports no new clinical outcomes.
September 2011 in “Journal der Deutschen Dermatologischen Gesellschaft” Effective treatments for scalp psoriasis include glucocorticosteroids, Vitamin D3 analogs, and combination therapies like calcipotriol and betamethasone dipropionate.
January 2011 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This study found that postmenopausal women experience two distinct patterns of hair changes, with diffuse scalp hair loss linked to body hair loss and age, and frontal hair loss associated with increased facial hair and a younger age.
January 2008 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” Healthy aging can be promoted through physical activity, lifestyle changes, and certain treatments.
January 2006 in “Carl von Ossiezky University of Oldenburg” This study observed that unpigmented keratinocytes saturate quickly with foreign substance uptake compared to pigmented melanocytes, where melanin significantly enhances binding.
January 2003 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This review discusses the dermatological impacts of hypogonadism in men, including skin thinning, reduced body hair, and skin reactions to testosterone therapy, but reports no new clinical results.
This dissertation reported that the loss of Ovol2 impairs hair follicle regeneration and wound repair in mice, highlighting its role in regulating directional migration of epithelial cells.
This study identified UBC22 as a novel E2 enzyme responsible for Lys11-linked ubiquitination in Arabidopsis, revealing its crucial roles in seed setting, female gametophyte development, and pathogen resistance.
11 citations
,
September 2010 in “American Journal of Medical Genetics - Part A” This study reports a mutation in the U2HR gene causing Marie Unna hereditary hypotrichosis in a Turkish family and notes eyebrow loss as a diagnostic clue.
181 citations
,
January 2009 in “Nature Genetics” In this study, researchers linked defects in U2HR, an inhibitory region in the HR gene, to Marie Unna hereditary hypotrichosis, suggesting a mechanism for controlling hair growth and addressing hair loss.
40 citations
,
October 2009 in “Journal of Biomedical Nanotechnology” This review discusses pyrene excimer nucleic acid probes for detecting biomolecules and protein-DNA interactions and reports no new experimental findings.