August 2026 in “Journal of Personalized Medicine” This narrative review proposes the concept of "repigmentation competence" for vitiligo lesions, suggesting that therapy responses are influenced by lesion-specific biological factors related to immune, regenerative, regulatory, and microenvironmental processes, and highlights the emerging role of combination therapies targeting these pathways.
June 2024 in “Computational and Structural Biotechnology Journal” This review discusses the integration of omics analyses in androgenetic alopecia research, reporting no new clinical results but suggesting that collaborative multi-omics studies may enhance understanding of AGA's pathomechanisms.
July 2023 in “Journal of Biomedical Science” In this review, the authors emphasize that phenotypic heterogeneity in genetic systems and human diseases is influenced by stochastic fluctuation and network topology, proposing that ultrasensitivity and threshold effects explain this variability, which may inform strategies for preventing and treating genetic diseases.
1 citations
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December 2022 in “JAMA Dermatology” This study found that the HairComb algorithm achieved high accuracy in quantifying percentage hair loss across various types of alopecia, suggesting its potential for standardized automated assessments.
79 citations
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August 1998 in “The Journal of Cell Biology” In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.
32 citations
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November 1998 in “Journal of Biological Chemistry” This study found that the unique functions of keratin 16 are likely determined by its tail domain, challenging the previous hypothesis about the role of the helix 1B subdomain.
29 citations
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December 2021 in “Biomedicines” This study found that exosomes from different mesenchymal stem cell sources had distinct effects on immune cell functions and varied microRNA expression profiles compared to their original cells.
26 citations
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January 2002 in “Advances in experimental medicine and biology” This article reviews the historical context of finasteride's development for BPH and its serendipitous discovery for hair growth, reporting no new research outcomes.
21 citations
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November 2023 in “International Journal of Molecular Sciences” This ex vivo study reported that melatonin significantly improved certain aging biomarkers in aged human skin, including reduced mTORC1 activity, increased fibrillin-1, and enhanced collagen and elastic fiber organization, though other key biomarkers remained unchanged.
15 citations
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June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identifies KLK14 as a significant factor contributing to hair defects and skin inflammation in a mouse model of Netherton syndrome.
15 citations
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December 2019 in “Aesthetic Surgery Journal” This study found that there is a low prevalence and wide variability in U.S. insurance coverage for ancillary gender surgeries, with specific criteria often required for favorable coverage.
14 citations
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July 1994 in “Journal of Dermatological Science” In this study, transgenic mice expressing a mutant K6 gene developed progressive scarring alopecia and keratosis, suggesting they may model a new keratin disorder.
13 citations
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May 2007 in “Journal of Endocrinology” This study found that A-ring reduced derivatives of norethisterone and levonorgestrel exhibit estrogen-like potency in rat osteoblasts, suggesting a mechanism for 19-norprogestins' bone restoration effects in postmenopausal women.
12 citations
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August 2022 in “Biochemical Journal” This review discusses the mechanisms of skin-associated cell death and their potential role in treating inflammatory skin diseases, but presents no new clinical findings.
4 citations
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August 2024 in “PLoS ONE” In this study, researchers reported that both progestin-only injectable contraceptives, DMPA-IM and NET-EN, significantly decreased serum testosterone and SHBG levels among HIV-negative women in South Africa, yet this did not explain prior findings of no reduction in risky sexual behavior or sexual function.
4 citations
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October 2021 in “Journal of Cellular and Molecular Medicine” This study observed that mature neutrophils and their extracellular traps inhibit wound-induced hair follicle neogenesis in mice, despite being stimulated by pro-regenerative cues.
2 citations
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July 2023 in “Agronomy” This study found that treating wheat with 100 µM melatonin under drought conditions significantly improved root and shoot growth, increased melatonin levels, and enhanced drought resistance, potentially clarifying the mechanisms of melatonin's protective effects in plants facing water scarcity.
1 citations
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October 2025 in “Current Issues in Molecular Biology” This research found that escin, when applied topically, enhances blood flow in human skin and promotes changes in endothelial cell signaling pathways, suggesting potential benefits for improving cutaneous microcirculation.
January 1983 in “Journal of the American Oil Chemists' Society” The U.S. soybean industry wanted government help due to foreign competition, while the jojoba industry was growing and expected to stabilize.
This review synthesizes current advances in transcriptomics and RNA regulatory networks, alongside stem cell-derived skin organoid research, to propose a conceptual framework for understanding and potentially guiding regenerative skin repair, without claiming clinical readiness.
March 2026 in “Applied Sciences” In this scoping review, researchers observed that while AI-assisted trichoscopy holds promise for standardized assessments of hair and scalp disorders, its clinical translation is limited by small proprietary datasets, inconsistent validation protocols, and a scarcity of real-world clinical studies.
May 2025 in “Frontiers in Bioinformatics” This study used computational methods to identify six molecules, with jamogenin being particularly promising, that effectively bind to and inhibit the enzyme linked to male pattern hair loss, suggesting these compounds could be explored further for hair growth potential.
February 2024 in “Cosmetics” In this study, researchers developed a novel platform for discovering potential hair loss inhibitors by investigating the testosterone/dihydrotestosterone biosynthetic pathway and its regulation through biochemical mechanisms involving 17β-HSD and 3β-HSD, combined with medicinal plant extracts.
November 2023 in “BMC women's health” In this study, certain haircare practices and age factors were found to be associated with the occurrence and severity of traction alopecia among women in Yaoundé.
June 2020 in “Journal of Investigative Dermatology” This symposium reviewed advances in understanding complex skin diseases through genetics and genomics, emphasizing the role of regulatory signals and environmental components in disease development, but reports no new clinical findings.
July 2019 in “Technology audit and production reserves” This research discusses the formulation of probiotic gel shampoos with whey peptides and plant extracts, highlighting their potential effectiveness and market feasibility in Ukraine.
2 citations
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September 2023 in “Aging” In this study, researchers found that Elastic Net DNA methylation clocks are not accurate for distinguishing between individuals or identifying health markers, but measuring biological "noise" in stable cytosines may serve as a potential biomarker of aging and disease.
2 citations
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May 2025 in “Archives of Dermatological Research” This retrospective cohort study found no significant association between Janus kinase inhibitors and increased malignancy risk in alopecia areata patients, but traditional immunosuppressants were linked to higher risks of internal and hematologic malignancies.
August 2024 in “International Journal of Molecular Sciences” The study investigated immune cell patterns around the hair follicle infundibulum in androgenetic alopecia, revealing significant differences in immune signatures between patients with AGA and control donors, specifically noting an enrichment of CD4 cells in the patient group.
January 2024 in “Wiadomości Lekarskie” This presentation will review neural networks and artificial intelligence basics, then explore their recent developments and applications in medical care, particularly in decision-making processes to enhance diagnostic accuracy and treatment strategies, ultimately improving patient outcomes in critical situations, as reported in this source.