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New liposome treatment successfully delivers CRISPR to deactivate a key enzyme in androgen-related disorders.

DHT in the human prostate is produced through multiple pathways, not just from testosterone.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Men on 5-alpha-reductase inhibitors might have worse COVID-19 outcomes.

Gardenia florida fruit extract may help hair grow and needs more research to understand how.

Finasteride and dutasteride are effective for male hair loss and enlarged prostate but may cause reversible sexual side effects.

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Hair loss can be managed with treatments like minoxidil, finasteride, and others, but there are still gaps in effectiveness and off-label usage is increasing.

Dihydrotestosterone and 5α-Reductase play a role in hair loss and prostate health, and finasteride can increase hair growth in men without affecting sperm production, but it doesn't work for postmenopausal women with hair loss.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Men who start losing hair at age 30 may have a lower risk of prostate cancer.

Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

The document discusses male and female pattern hair loss, its diagnosis methods, FDA-approved treatments like finasteride and minoxidil, their side effects, and the role of lifestyle changes.

Origanum vulgare leaf extract reduces liver and kidney damage caused by finasteride in mice.

Fish oil increased cell growth and macrophages in the skin but didn't affect COX-2 expression.

The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.

CRISPR/Cas9 has improved precision and control but still faces clinical challenges.

Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.

More personalized and effective treatments for androgenetic alopecia are needed.

5α-Reductase inhibitors may increase depression risk but not dementia or suicide.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Mutations in Plcd1 and Plcd3 together cause severe hair loss in mice.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

Rice bran extract might help prevent hair loss.