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The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.

Androgens and a high-fat diet may increase the risk of severe COVID-19 in women with PCOS by upregulating certain proteins in the heart and kidneys.

Androgens, male hormones, affect physical and mental functions, with a decrease leading to health issues like muscle loss, bone disease, and depression, and more research is needed on long-term effects and treatments.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Recent genetic insights show that low-renin hypertension includes a range from essential hypertension to secondary or familial forms, affecting diagnosis and treatment.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Hormones like testosterone and estrogen significantly affect hair growth and structure.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Male androgenetic alopecia involves hair follicle miniaturization due to DHT, with potential treatments using inhibitors and blockers.

The research identified two types of keratinocytes in chicken scales: one for hard scales and another for soft skin, with similarities to human skin differentiation.

Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

DHT, a testosterone byproduct, causes male pattern baldness.

Testosterone may slow down wound healing and increase inflammation.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

Genes linked to wool fineness in sheep have been identified.

Different genes are active in dogs' hair growth and skin, similar to humans, which helps understand dog skin and hair diseases and can relate to human conditions.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Steroidogenic isoenzymes may help improve treatments for common hair loss.