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New liposome treatment successfully delivers CRISPR to deactivate a key enzyme in androgen-related disorders.

Androgenetic alopecia, or hair loss, is caused by a mix of genetics, hormones, and environment, where testosterone affects hair growth and causes hair to become smaller and grow for a shorter time.

DHT in the human prostate is produced through multiple pathways, not just from testosterone.

Men on 5-alpha-reductase inhibitors might have worse COVID-19 outcomes.

PRP is effective for treating hair loss, especially with other treatments.

Dutasteride may help treat prostate cancer by causing cancer cells to shrink and die.

Stauntonia hexaphylla extract can help treat hair loss by blocking certain hormones.

Finasteride and dutasteride may cause metabolic issues like liver disease and diabetes.

Hair loss can be managed with treatments like minoxidil, finasteride, and others, but there are still gaps in effectiveness and off-label usage is increasing.

The document discusses male and female pattern hair loss, its diagnosis methods, FDA-approved treatments like finasteride and minoxidil, their side effects, and the role of lifestyle changes.

Finasteride may lower cholesterol and slow heart disease progression.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Genes and hormones cause hair loss, with four genes contributing equally.

Finasteride and dutasteride are effective for male hair loss and enlarged prostate but may cause reversible sexual side effects.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Women with androgenetic alopecia have lower zinc and iron levels.

5α-reductase inhibitors may worsen sexual drive and spontaneous erections but don't worsen existing erectile or ejaculatory problems.

Allopregnanolone changes gene expression in glioblastoma cells.

Minoxidil and finasteride can slow or halt hair loss, but may have side effects.

Orthosiphon stamineus leaf extract reduces oily skin and improves complexion better than zinc gluconate.

Topical finasteride with EGCG or TA improves drug release and dermal uptake, potentially treating hair loss effectively.

Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

PAD3 plays a key role in hair and skin protein structure and may be linked to skin diseases.

Some hair loss can be treated, especially in women due to nutrition, but some types remain untreatable.

The study concluded that changing the culture conditions can cause sika deer skin cells to switch from a flat to a 3D pattern, which is important for creating hair follicles.

The review suggests limited treatments for common hair loss conditions, with potential for future improvements.

Fish oil increased cell growth and macrophages in the skin but didn't affect COX-2 expression.