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Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Preventing hair loss is more effective than regrowth; oral finasteride is a realistic option.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

A new plant extract from Avicennia marina could potentially be used to treat common hair loss.

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

Finasteride doesn't affect erections much, but may decrease libido in men.

Testosterone helps human pancreatic cells increase insulin release.

Chaga mushrooms contain compounds that may promote hair growth better than common treatments.

The study created a new method to test drugs that affect hormone processing in skin.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Different human traits like skin color and hair type vary between populations due to genetic adaptations to the environment.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Over 150 new molecules with biological activities were found in traditional herbal medicines, some with potential for new drug development.

Dutasteride effectively treats benign prostatic obstruction, improves urinary flow, reduces prostate size, and may prevent prostate cancer, but can cause sexual side effects.

Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

5-alpha reductase inhibitors might worsen lung recovery in COVID-19 patients, suggesting a pause in their use.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Compounds from the plant Mammea siamensis may help treat hair loss.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Some plants with flavonoids may help treat hair loss and promote hair growth.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

Topical finasteride doesn't reduce DHT levels, hinting at an endocrine role in hair loss.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.