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5AR inhibitors like finasteride and dutasteride improve hair growth and slow hair loss in male pattern baldness.

Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.

Blocking the enzyme that turns testosterone into DHT can safely and effectively treat enlarged prostate.

Allergic reactions to blood thinners are rare but can be serious, requiring careful management and alternative treatments.

Minoxidil and finasteride can slow hair loss and stimulate regrowth, but won't restore all lost hair or reverse complete baldness.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

5α reductase type 2 enzyme mutation and oxidative stress may increase androgenetic alopecia risk in Egyptians.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

Preventing hair loss is more effective than regrowth; oral finasteride is a realistic option.

Sebocytes play a key role in controlling androgen levels in human skin.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Finasteride effectively reduces hair loss by decreasing androgen levels.

There is no clear recommendation for using selenium in cancer patients; it may be beneficial to correct low selenium levels before treatment.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Male androgenetic alopecia involves hair follicle miniaturization due to DHT, with potential treatments using inhibitors and blockers.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride is not expected to be effective for treating Acne vulgaris.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.