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The medications 5α-reductase inhibitors and spironolactone are generally safe for breast cancer patients on endocrine therapies and do not significantly increase breast cancer risk.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride negatively affects fish reproduction and gonadal development.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Men with Type 2 Diabetes have lower DHT levels, which may affect fertility and lipid profiles.

Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Dutasteride reduces DHT more effectively than finasteride.

Dutasteride more effective for hair growth, but has more side effects than finasteride.

5-α-reductase inhibitors reduce prostate cancer risk but may cause sexual dysfunction and don't affect high-grade tumor or death rates.

Finasteride exposure harms tadpole reproduction and hormone balance.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Low-dose finasteride effectively treats hirsutism, is safe, and cost-effective.

Low-dose finasteride and dutasteride reduce PSA levels by 27.8% in men with male androgenetic alopecia.

Personalized treatments for hair loss are becoming more effective by using genetic information.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Finasteride and dutasteride effectively treat hair loss in men and women, but may cause side effects like low libido and depression.

5α-reductase inhibitors can interfere with doping tests by masking banned substances.

Finasteride improves hair growth in men with androgenetic alopecia.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

Taking oral testosterone with finasteride or dutasteride doubles testosterone levels, and food slightly affects it.