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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Finasteride improves hair loss in women with hyperandrogenism.

Dutasteride is more effective than finasteride for hair loss treatment.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.

Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.

Testosterone helps human pancreatic cells increase insulin release.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Finasteride exposure harms tadpole reproduction and hormone balance.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

Treat hair loss with finasteride, minoxidil, or surgery; consider side effects and severity.

Suppressing certain hormones might help prevent prostate cancer.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

Finasteride negatively affects fish reproduction and gonadal development.

Some diseases can improve the outcomes of other diseases, leading to new treatment possibilities.

Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.

Finasteride doesn't harm male fertility or sperm quality, but may slightly reduce ejaculate volume.

Dutasteride is effective for treating prostate enlargement and reducing related surgery risk, but is not approved for preventing prostate cancer.

Male pattern baldness is often genetic and linked to a hormone, with treatments like finasteride and minoxidil being effective for some men.

Longer CAG repeats in gene linked to more severe hair loss in females.