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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

Taking both finasteride and dutasteride for prostate issues may raise the risk of heart problems.

Hormones, especially androgens, play a key role in causing acne, and treatments like hormone control pills and hormone-blocking medications can help.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

Ginseng, especially red ginseng, may help regrow hair and block a hair loss-related enzyme.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Finasteride improves hair growth in men with androgenetic alopecia.

Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

Genetic factors affect hair loss, and molecular testing may help predict, diagnose, and treat it.

Finasteride effectively treats baldness but may cause sexual side effects.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Taking finasteride for benign prostate hyperplasia may increase the risk of osteoporosis, especially at higher doses.

Longer TA repeats in the SRD5A2 gene may increase acne risk in Chinese people.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

Shallot extract may help with hair growth and treating hair loss.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.