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The rat model showed early perimenopause with regular cycles and low hormones, and late perimenopause with irregular cycles and higher hormone levels.

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

Blocking 11β-HSD1 can lessen the harmful effects of glucocorticoids on hair growth cells.

Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.

Hair characteristics might be early signs of Type 2 Diabetes and could help with early prevention.

17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

Patients with myotonic dystrophy often have skin problems that suggest early aging and vitamin D issues, and the severity of these problems is linked to their genetic condition and vitamin D levels.

Finasteride effectively treats male hair loss, improving growth and density.

Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.

A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.

The document concludes that the human keratin gene cluster is complex, with a need for updated naming to reflect over 50 functional genes important for hair and skin biology.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.

Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.

Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

ILC1-like cells can cause alopecia areata by attacking hair follicles.

The CRH/CRH-R1 system might be involved in causing lichen planus.