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Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Dutasteride more effective for hair growth, but has more side effects than finasteride.

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Current treatments for male pattern baldness include minoxidil and finasteride, with new options being developed.

Finasteride improves hair growth and reduces hirsutism in women, but side effects and optimal dosages need further research.

The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.

Hair disorders are caused by a complex mix of biology, genetics, hormones, and environmental factors, affecting hair growth and leading to conditions like alopecia.

Sex hormones affect hair and feather growth and may help manage alopecia and hormone-dependent cancers.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

Prostate cancer was a major health issue in 2009, especially for Black men, and targeting the 5alpha-reductase enzyme could help in its prevention and treatment.

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.