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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

Primary care is key in managing PCOS, focusing on lifestyle changes and medications like birth control and metformin.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

Prostate-specific antigen may be a new marker for excess male hormones in women with polycystic ovary syndrome.

Women with PCOS have fewer activated T cells in their ovarian follicles, which might affect fertility.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

Early treatment of PCOS in teens is crucial to prevent long-term health issues like diabetes and heart disease.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.

A man with testotoxicosis was fertile despite low FSH levels, suggesting high testosterone may allow sperm production without FSH.

PCOS has a strong genetic basis, but more research is needed to fully understand it.

Agmatine may help reduce seizures linked to hormone changes in female rats.

Lifestyle changes are the first step in treating infertility in PCOS, followed by medications like clomiphene and metformin, and then surgery if needed.

The document explains how male reproductive hormones work and affect the body.

Two types of 5α-reductase are in dog skin, which might make dutasteride better than finasteride for treating dog hair loss.

Women with a certain type of tumor had higher levels of pregnancy hormone and male hormones, which decreased after treatment.

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

Women with PCOS who have high male hormone levels often also have insulin resistance.

The new rodent model successfully mimics non-lean human PCOS symptoms.

New tools show that in fish, NPY increases feeding and somatostatin decreases it.

The document suggests various treatments for PCOS, including medication for menstrual issues, insulin resistance, and excess hair, as well as fertility treatments, while highlighting the need for personalized care and lifestyle changes.