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This case study details a 57-year-old woman with symptoms of androgen excess, including rapid hair growth and temporal balding, alongside abnormal testosterone levels and a history of chronic renal failure.

This study found that NLRP1 in human melanoma cells promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity.

This review explores the complex, context-dependent roles of tumor-secreted proteins and suggests that some proteins traditionally seen as tumor-promotive may act as tumor-suppressors in different environments, emphasizing the influence of cell fitness and treatment exposure.

This study found that NKIRAS2 expression affects skin tumor suppression and HRAS-driven transformation in mice, indicating its role in carcinogenesis depends on expression level and cellular context.

This study observed that COX-2 overexpression in transgenic mice led to a significant reduction in skin tumor development compared to controls, challenging the expected role of COX-2 in promoting tumors.

This study found that ING5 knockout mice are prone to developing lymphomas and severe dermatitis, suggesting ING5 plays a role in tumor suppression and stem cell maintenance in vivo.

The study observed that the tumor suppressor activity of bone morphogenetic proteins in mouse skin epithelium depends on Noggin levels, inhibiting Wnt and Shh signaling pathways to prevent tumor initiation and progression.

This study suggests that targeting the tumor stroma to promote the formation of dermal condensates may offer a novel approach to treating basal cell carcinoma.

This study found that elevated androgens in the brains of glioblastoma patients are produced by tumor cells, and overexpressing Sirt1 reduces these levels, thereby delaying tumor progression more effectively than conventional therapy in mouse models.

In this study with mice, simultaneous inactivation of Smad4 and PTEN genes led to rapid development of invasive forestomach squamous cell carcinomas, mirroring human esophageal SCCs.

In this study, the deletion of Smad4 and PTEN genes in mice was associated with rapid and invasive squamous cell carcinoma formation in the forestomach, modeling human esophageal cancer progression.

This study found that hinokitiol effectively suppressed TNF-α production in activated macrophage-like cells, suggesting it may help alleviate hair loss by mitigating factors that promote follicular apoptosis.

Fgfr2b helps maintain healthy skin and prevent cancer.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

This symposium reviewed various advances in understanding and potentially reversing skin aging, with no new experimental results reported.

This review discusses the roles of human tissue kallikreins in skin physiology and pathology and reports no new findings, emphasizing their potential involvement in various skin functions and conditions.

This article reviews existing knowledge on postmenopausal hyperandrogenism and highlights diagnostic challenges, reporting no new clinical results.

This article compares the immunology of cancer and the placenta and suggests that immunotherapy for pregnant cancer patients could be feasible with careful exploration, though no new clinical results are reported.

In this study, a 37-year-old female with resistant hypertension and signs of Cushing's syndrome and primary aldosteronism was found to have normal cortisol levels but high levels of cortisol and aldosterone via adrenal venous sampling, leading to a diagnosis confirmed by right adrenalectomy.

This review discusses the diagnosis and treatment of hirsutism, emphasizing that a systematic evaluation can determine its cause, while combination therapy effectively manages the condition for most patients.

This article reviews current evaluation and treatment options for androgenic alopecia in women and reports no new clinical results.

This review discusses the definition, pathogenesis, diagnosis, and management of hirsutism and reports no new clinical results.

This article discusses various causes of hyperandrogenism in women and highlights diagnostic considerations for conditions such as PCOS, NCCAH, Cushing's disease, and androgen-secreting tumors, without reporting new clinical results.

This article discusses the factors influencing anticancer therapeutic regimens and reviews mechanisms of action and side effects of major chemotherapeutic agents without reporting new research findings.

This study reported that testosterone levels over 150 ng/dL combined with lack of testosterone suppression during a low-dose dexamethasone suppression test may indicate androgen-producing tumors, though this wasn't consistent across all cases.

This review discusses diagnostic and management approaches for hirsutism, emphasizing that most cases are due to polycystic ovary syndrome or obesity-related disorders, with idiopathic hirsutism often treated cosmetically.

This review discusses the causes and treatment strategies for hirsutism, emphasizing that combination therapy targeting androgen suppression and hair removal techniques is most effective; no new clinical results are reported.

This study found that quiescence in hair follicle stem cells acts as a tumor suppression mechanism for cutaneous squamous cell carcinoma, with Pten activity necessary to maintain this state.

This study identified a set of tumour-suppressive microRNAs (miRNAs), termed 'normomiRs', that are highly expressed in normal tissues but low in tumors, with miR-206 and miR-381 showing significant in vitro cancer inhibition, highlighting their potential for miRNA-replacement therapies across multiple cancer types.

This study found that nanobubble-encapsulated diclofenac with ultrasound-targeted microbubble destruction (DNBs-UTMD) can enhance the anti-tumor efficacy of Doxil® by regulating the tumor immune microenvironment, improving drug uptake, and increasing T cell responses while reducing immune-suppressive cells in the process.