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GlossaryNeoplasms (Tumors)

abnormal tissue growths from uncontrolled cell division

Neoplasms, also known as tumors, are abnormal growths of tissue that arise from uncontrolled cell division. They can be benign (non-cancerous) or malignant (cancerous), with malignant neoplasms having the potential to invade nearby tissues and spread to other parts of the body.

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Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

research Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

174 citations , February 2017 in “Cell stem cell”

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

research Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment

153 citations , June 2015 in “GenomeBiology.com”

The environment around the time of conception can change the VTRNA2-1 gene in a way that lasts for years and may affect disease risk.

research Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

81 citations , November 2012 in “Journal of the National Cancer Institute”

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

research Induction of dark keratinocytes by 12-O-tetradecanoyl-phorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency

77 citations , January 1980 in “Carcinogenesis”

TPA is about 50 times more effective at promoting tumors than MZ.

research Silk‐Inspired In Situ Hydrogel with Anti‐Tumor Immunity Enhanced Photodynamic Therapy for Melanoma and Infected Wound Healing

59 citations , February 2021 in “Advanced Functional Materials”

The silk fibroin-based hydrogel shows promise for treating melanoma and healing infected wounds by killing tumor cells and bacteria, and supporting skin recovery.

research The Vitamin D Receptor as Tumor Suppressor in Skin

55 citations , January 2020 in “Advances in experimental medicine and biology”

Vitamin D and its receptor may help prevent skin cancer.

research Roles of tumor suppressors in regulating tumor-associated inflammation

44 citations , September 2014 in “Cell Death & Differentiation”

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

research Tumor Mapping in 2 Large Multigenerational Families With CYLD Mutations

44 citations , November 2009 in “Archives of Dermatology”

CYLD mutations cause a variety of skin tumors with symptoms starting around age 16, and treatments are currently limited.

research Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis

29 citations , July 2014 in “PloS one”

Meis1 is crucial for skin health and tumor development.

research Tumor Necrosis Factor-Alpha and Polycystic Ovarian Syndrome: A Clinical, Biochemical, and Molecular Genetic Study

26 citations , September 2014 in “Genetic Testing and Molecular Biomarkers”

High levels of TNF-α may contribute to obesity and insulin resistance in PCOS, but not due to the C850T genetic variation.

research Mommy — where do tumors come from?

16 citations , May 2011 in “The Journal of clinical investigation/The journal of clinical investigation”

Some skin tumors may start from hair follicle stem cells.

research Tumor Necrosis Factor in Sepsis

13 citations , March 1990 in “JAMA”

Topical eye β-blockers might cause hair loss, which usually gets better after stopping the medication.

research Tumor Promotion in Skin: Are Active Oxygen Species Involved?

10 citations , January 1985 in “Elsevier eBooks”

Active oxygen species might be involved in skin tumor growth, but their exact role is unclear.

research Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis

7 citations , February 2022 in “Stem cell reviews and reports”

Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.

research Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis

5 citations , May 2020 in “Life science alliance”

Removing integrin α3β1 from hair stem cells lowers skin tumor growth by affecting CCN2 protein levels.

Optimal placement of Burow's triangles for aesthetically pleasing repair of multiple defects using local flaps after tumor excision

research Optimal placement of Burow's triangles for aesthetically pleasing repair of multiple defects using local flaps after tumor excision

3 citations , August 2018 in “Journal der Deutschen Dermatologischen Gesellschaft”

The technique effectively repairs skin after tumor removal, maintaining appearance and function without complications.

Possible association between androgenic alopecia and risk of prostate cancer and testicular germ cell tumor: a systematic review and meta-analysis

research Possible association between androgenic alopecia and risk of prostate cancer and testicular germ cell tumor: a systematic review and meta-analysis

3 citations , March 2018 in “BMC Cancer”

Baldness, especially at the front, may lower the risk of testicular cancer by 31%, but its link to prostate cancer is unclear.

Perifolliculitis capitis abscedens et suffodiens treatment with tumor necrosis factor inhibitors and baricitinib: A case report and literature review

research Perifolliculitis capitis abscedens et suffodiens treatment with tumor necrosis factor inhibitors and baricitinib: A case report and literature review

2 citations , March 2023 in “Frontiers in medicine”

A 15-year-old boy's severe scalp condition improved significantly with adalimumab and baricitinib treatment.

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women

research Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women

2 citations , February 2023 in “BMC women's health”

Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.

research Hair Loss Induced by Tumor Necrosis Factor Alpha Inhibitors

2 citations , January 2014 in “Journal of clinical and investigative dermatology”

Some drugs used to treat immune conditions may cause different types of hair loss.

research Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation

2 citations , July 2017 in “Oncology Letters”

Lacking cyclin D3 reduces skin cancer growth without affecting normal skin cell growth.

research Keratinic amyloid deposition in canine hair follicle tumors

1 citations , October 2022 in “Veterinary pathology”

Some canine hair follicle tumors contain amyloid deposits, with a protein called CK5 involved in their formation.

research Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice

1 citations , December 2020 in “International journal of molecular sciences”

External factors can cause skin cancer cells that usually don't spread to grow and form tumors in mice.

research Tumor necrosis factor-alpha inhibitor associated psoriasiform alopecia (drug-induced psoriasiform alopecia)

1 citations , April 2012 in “Informa Healthcare eBooks”

Some medications for inflammation can cause a condition with scalp rashes and hair loss, often linked to Crohn's disease, and may require treatment changes to prevent permanent hair loss.

research The role of Wnt and Shh signaling systems in noggin-induced tumorigenesis

March 2024 in “Vestnik Rossijskogo universiteta družby narodov. Seriâ Agronomiâ i životnovodstvo”

Wnt and Shh signaling are key in noggin-induced tumors, and blocking them can slow tumor growth.

research Tumor necrosis factor inhibitors and janus kinase inhibitors in the treatment of cicatricial alopecia: A systematic review

February 2024 in “PloS one”

Tofacitinib and adalimumab are promising treatments for cicatricial alopecia with few side effects.

research Microinjury-Induced Tumor Necrosis Factor-α Surge Stimulates Hair Regeneration in Mice

January 2023 in “Skin Pharmacology and Physiology”

Minor injuries to hair follicles can stimulate hair growth in mice by increasing a specific protein.

research Psoriatic Alopecia in a Patient With Crohn Disease: An Uncommon Manifestation of Tumor Necrosis Factor α Inhibitors

April 2021 in “Cutis”

A girl with Crohn's disease developed hair loss due to her increased medication, a rare side effect seen in some children.

A Cellular Study of Inflammatory Responses in Women with Polycystic Ovary Syndrome as: “An In vitro Model of Anti Breast Tumor Response”A Case Control Study

research A Cellular Study of Inflammatory Responses in Women with Polycystic Ovary Syndrome as: “An In vitro Model of Anti Breast Tumor Response”A Case Control Study

April 2020 in “Research Square (Research Square)”

Women with PCOS may have a reduced ability to fight breast tumor cells over time.

Dual aspects of B cells in tumor immunity; B cells are capable of positive and negative regulation for tumor immunity against B16 melanoma

research Dual aspects of B cells in tumor immunity; B cells are capable of positive and negative regulation for tumor immunity against B16 melanoma

May 2017 in “Journal of Dermatological Science”

B cells can both help and hinder the body's defense against melanoma.