This review outlines current treatments for folliculitis decalvans and dissecting cellulitis of the scalp, noting conventional therapies' limitations and promising but limited results from targeted biologic agents.
October 2014 in “Cancer research” This study found that targeting mTORC1 with rapamycin effectively inhibited skin tumor promotion in a mouse model, highlighting a potential target for cancer chemoprevention.
48 citations
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January 2014 in “Dermatology Online Journal” This review examines various treatments for dissecting cellulitis, noting isotretinoin may offer the best chance for remission despite limited long-term data and calls for more clinical studies.
24 citations
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August 2020 in “JAMA dermatology” In this study, researchers observed a dose-dependent occurrence of persistent radiation-induced alopecia in patients with primary CNS tumors or head and neck sarcomas, noting distinctive patterns and features, and suggesting potential benefits of topical minoxidil and procedural interventions for treatment.
16 citations
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April 2014 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This report describes a case of universal alopecia in a patient with rheumatoid arthritis while using adalimumab and leflunomide, suggesting a potential link between these drugs and alopecia areata.
15 citations
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January 2019 in “Mediators of inflammation” This study concluded that Aloe vera fermentation significantly accelerates burn injury healing in rats by reducing inflammation and altering gut microbiota composition.
This chapter reviews recent developments in vitiligo research, highlighting the role of melanocyte stem cell differentiation and oxidative stress in its management, but reports no new clinical results.
In this study, 30 patients with alopecia areata received intralesional methotrexate injections, resulting in significant hair regrowth and decreased levels of lesional TNF-α after three months, suggesting its effectiveness as a treatment.
June 2022 in “Frontiers in Immunology” This report describes a case of alopecia universalis successfully treated with tofacitinib, though it was associated with increased peripheral blood cytokine levels.
6 citations
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February 1974 in “The BMJ” The document concludes that scalp disorders can be treated with hair washing, specific shampoos, medications, and sometimes surgery or hair transplants, but hereditary baldness is untreatable.
74 citations
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July 2010 in “The Journal of Clinical Endocrinology & Metabolism” This study found that gonadal dysfunction is very common in premenopausal women with acromegaly and may be caused by hyperprolactinemia, GH/IGF-I excess, or tumor effects.
25 citations
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May 2018 in “Clinical & Translational Oncology” This review summarizes common skin-related side effects of BRAF inhibitors and immunotherapy in advanced melanoma treatment, reporting no new clinical findings, and emphasizes consensus management to improve patient outcomes.
12 citations
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July 2012 in “Journal of cutaneous medicine and surgery” This study reported that adalimumab was well tolerated in patients with severe alopecia areata but did not lead to significant hair regrowth.
9 citations
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February 2021 in “Evidence-based Complementary and Alternative Medicine” This study reported that Longdan Xiegan decoction is more effective than conventional western medicine alone in treating eczema, but the evidence quality was generally low, highlighting the need for further studies.
April 2020 in “Journal of the Endocrine Society” In this case study, the use of somatostatin analogues was effective in localizing and confirming a neuroendocrine lung tumor as the source of ectopic ACTH syndrome, leading to marked clinical improvement in a patient unable to undergo surgery.
8 citations
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May 1991 in “PubMed” This case study from Boston University details a 35-year-old woman diagnosed with congenital adrenal hyperplasia, treated with dexamethasone, leading to normalized androgen levels and successful conception.
6 citations
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February 2022 in “Journal of immunology research” This study observed that exosomes from adipose-derived stem cells promoted hair growth by enhancing dermal papilla cell proliferation and activating signaling pathways, suggesting potential for treating immune-mediated alopecia.
3 citations
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November 2005 in “Women's health” This narrative review discusses various causes and treatments of hirsutism in women, emphasizing the importance of identifying androgen-secreting tumors, but does not present new study results.
3 citations
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May 2002 in “PubMed” This article reviews the causes and treatments of hypertrichosis and hirsutism and reports no new clinical findings; the authors compare diagnostic strategies and discuss available treatment options.
2 citations
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September 2004 in “Fertility and sterility” This review discusses the cosmetic and health implications of hirsutism and highlights its potential link to serious underlying disorders, but it presents no new clinical findings.
March 2025 in “Ukrainian Journal of Dermatology Venerology Cosmetology” This review highlights the crucial role of the immune system in hair follicle regulation and its potential link to autoimmune disorders like alopecia areata. It suggests that understanding immune-mediated hair regeneration could lead to new treatments for this condition.
91 citations
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March 1996 in “Archives of Dermatological Research” This study concluded that cytokines and growth factors significantly regulate hair growth in vitro, with some completely inhibiting growth, such as EGF and TNFα.
10 citations
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October 2011 in “Dermatologica Sinica” This case report describes a patient who developed multiple skin reactions, including eczematous lesions and alopecia areata, during adalimumab treatment, but found no improvement in pustulosis palmoplantaris with different biologics.
December 2022 in “Research Square (Research Square)” This study found that an extract from the herbal medicine Ophioglossum vulgatum Linn. showed potential hair growth promotion and increased ATP and catalase activity in cell assays, suggesting its use in treating alopecia.
3 citations
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January 1988 in “PubMed” This study found that scalp basal cell carcinomas do not appear to behave more aggressively than other types, despite suggestions in the literature.
52 citations
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May 2013 in “Supportive Care in Cancer” Scalp cooling significantly reduces hair loss in chemotherapy patients.
23 citations
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June 1945 in “Annals of Internal Medicine” This clinical study explores the causes, progression, and treatment of hirsutism in females, noting its association with tumors in endocrine glands, but does not report new clinical results.
10 citations
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August 2023 in “Advanced Science” This review discusses nitric oxide's physiological roles and the development of strategies for delivering it exogenously, without presenting new clinical results.
October 2020 in “Veterinary Dermatology” This review discusses autoimmune blistering diseases across species and highlights new treatment efficacy findings and ongoing trials, but it reports no new clinical results.
December 2002 in “Operative Techniques in Otolaryngology-head and Neck Surgery” This article reviews techniques for restoring appearance following scalp injuries and highlights the versatility of scalp expansion, advancement flaps, and follicular unit hair transplantation, but it provides no new clinical results.