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5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Skin fat helps with body temperature control and has other active roles in health.

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

Finasteride may reduce prostate bleeding by lowering blood vessel growth factor levels and blood vessel density in certain prostate areas.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

The document concludes that diagnosing and treating Human African Trypanosomiasis is challenging, but new treatments like fexinidazole are promising.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Vitiligo affects overall health and self-esteem, needing more research and awareness.

New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Mesenchymal stem cells show potential for skin healing and anti-aging, but more research is needed for safe use, especially regarding stem cells from induced pluripotent sources.

The dermal regeneration template is effective in skin regeneration, reducing scarring, and has potential for future improvements.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

Electrospun nanofibers show promise for enhancing blood vessel growth in tissue engineering but need further research to improve their effectiveness.

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

Fat-derived stem cells, platelet-rich plasma, and biomaterials show promise for healing chronic skin wounds and improving soft tissue with few side effects.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.

SAHA syndrome is a condition in women involving skin and hair issues, often related to hormonal imbalances, and is treated based on the underlying cause.

Advanced human skin models improve drug development and could replace animal testing.

FFA's causes may include environmental triggers and genetic factors.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.