August 2026 in “Journal of Cosmetic Dermatology” This systematic review reported that both hair transplantation and topical minoxidil were associated with cosmetic improvement in patients with temporal triangular alopecia, but noted that the evidence is based on low-level studies and highlighted the need for higher-quality research, especially in pediatric populations.
September 2024 in “Quality in Sport” This study provides a comprehensive review of trichotillomania, focusing on its clinical symptoms, etiology, diagnostics, and treatment methods, while also addressing serious complications like trichobezoars and Rapunzel Syndrome.
17 citations
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September 2009 in “British Journal of Dermatology” This study suggests that clinically apparent fragile hair in children is rarely linked to trichothiodystrophy, and the tiger-tail pattern is not wholly specific to this diagnosis.
13 citations
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August 2018 in “Clinical Chemistry” This study determined that a total testosterone concentration of ≥5.1 nmol/L identified androgen-producing tumors in women with severe hyperandrogenemia, while a lower threshold of ≥2.2 nmol/L was found for diagnosing pathologic hyperandrogenism in postmenopausal women.
3 citations
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February 2023 in “BMJ Case Reports” This case report describes a woman with trichotillomania who experienced marked improvement and hair regrowth after off-label onabotulinumtoxinA treatment.
3 citations
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January 2016 in “International Journal of Contemporary Pediatrics” This study reviewed 78 childhood trichotillomania cases and found the scalp was the primary site for hair pulling, with comorbid psychiatric disorders present in many cases.
1 citations
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January 2025 in “medRxiv” In this case-control study, researchers did not find genome-wide significant genetic variants for trichotillomania, but cases had higher polygenic risk for psychiatric disorders and certain neuropsychiatric-associated copy number variants.
1 citations
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January 2010 in “SRX Pharmacology” This study found that bupropion SR may improve symptoms in female trichotillomania patients who did not respond to SSRIs, with benefits maintained through a 16-month follow-up.
November 2023 in “PubMed” This study found significant gender differences in total testosterone and dehydroepiandrosterone sulfate levels among noncritical COVID-19 patients, which were associated with severity markers in males.
October 2025 in “Indian Dermatology Online Journal” In this case report, researchers documented a young girl's eyebrow hair loss attributed to trichotillosis influenced by observing Jain monks' ritualistic hair plucking, highlighting the role of cultural practices in shaping compulsive behaviors.
January 2025 in “International Journal of Trichology” This case report documents a rare instance of body-focused repetitive behavior in a 37-year-old male physician who compulsively pulled hair from his thighs due to exam stress, highlighting the variability in presentation and demographics of such disorders and the potential for psychiatric comorbidity.
June 2023 in “Animal Bioscience” This study observed that vimentin and transthyretin proteins were more highly expressed in black sheep skins compared to white, suggesting their involvement in coat color formation.
3 citations
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January 2019 in “Česká a slovenská farmacie” This review discusses various types of microneedles and their potential to expand the range of drugs delivered via the skin, but reports no new clinical results.
This case report details a 28-year-old male who developed trichotillomania following a traumatic brain injury, highlighting diagnostic challenges in distinguishing overlapping psychiatric and compulsive behaviors, and underscores the importance of a comprehensive, multidisciplinary treatment approach.
November 2025 in “International Journal Of Ayurvedic And Herbal Medicine” In this case study, a 22-year-old female with trichotillomania showed significant improvement through an integrated approach combining Growth Factor Concentrate therapy, Ayurvedic medications, counseling, and yogic practices, highlighting the importance of addressing both dermatological and psychological aspects for long-term recovery.
August 2025 in “Psychiatry and Clinical Neurosciences Reports” This case report describes a woman who developed trichotillomania during long COVID and saw improvement in symptoms with the SSRI escitalopram.
May 2022 in “European medical journal” This case report highlights a rare instance of gastric trichobezoar, or "Rapunzel syndrome," associated with trichotillomania, characterized by hair accumulation in the stomach of a patient.
May 2022 in “European medical journal” This case report describes a rare instance of a patient with trichotillomania also developing a gastric trichobezoar, leading to Rapunzel syndrome.
January 2020 in “International Journal of Trichology” This study reported that platelet-rich plasma injections led to only temporary improvement in vellus hair characteristics in temporal triangular alopecia, suggesting it may not be an effective long-term treatment.
11 citations
,
August 2020 in “Diabetes” This study found that testosterone enhances insulin secretion in human pancreatic islets by being converted into DHT and E2, processes that are necessary for this effect.
205 citations
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January 2005 in “Skin pharmacology and physiology” This review discusses how liposomes and niosomes can enhance drug penetration in topical delivery systems and emphasizes the importance of their specific composition, size, and type, but it reports no new results.
53 citations
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March 2006 in “Biopolymers” This study suggests that increased amounts of less stable disulfide conformers in hair shafts may be linked to the brittleness observed in trichothiodystrophy.
26 citations
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April 2021 in “Materials & Design” This study found that composite chitosan nanofibers containing luminescent europium complexes can sensitively detect Cu2+ concentrations as low as 10 μmol/L, making them suitable for use in biological systems.
6 citations
,
January 2014 in “American Journal of Medical Case Reports” This case report highlights a 17-year-old girl with overlapping features of thrombotic thrombocytopenic purpura and systemic lupus erythematosus, emphasizing the critical importance of early diagnosis and intensive therapy including plasma exchange.
April 2017 in “Journal of Investigative Dermatology” In this study, deep phenotyping of 68 patients with XPD gene defects successfully separated individuals by clinical diagnosis and survival status, potentially improving diagnosis and prognosis for xeroderma pigmentosum and trichothiodystrophy.
This study successfully established a functionally stable immortalized sheep granulosa cell line (GCs-SV40T-GFP) that can passaged up to 50 generations, maintaining morphological stability and estradiol secretion, offering a valuable model for research into animal reproductive function and hormone regulation.
132 citations
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February 2002 in “Journal of Biological Chemistry” This study demonstrated that HOXC13 directly influences hair keratin gene expression by binding to specific DNA motifs, suggesting its role in early hair follicle differentiation.
37 citations
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January 2017 in “International Journal of Dermatology” This study found that trichoscopic features like exclamation mark hairs and angulated hairs were more indicative of alopecia areata in an Asian population, while features like broken hairs of different lengths and flame hairs were more common in trichotillomania.
22 citations
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September 2024 in “Human Reproduction Update” This study found that total testosterone and free testosterone are recommended as first-line tests for diagnosing biochemical hyperandrogenism in women with PCOS; liquid chromatography with tandem mass spectrometry is preferred for its accuracy.
15 citations
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August 2013 in “Gene” This study found that the MTHFR gene C677T mutation appears to be a susceptibility factor for alopecia areata in the Turkish population.