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This study found that a specific VDR amino acid substitution in children with hereditary vitamin D-resistant rickets disrupts ligand binding and gene activation but does not impair hair follicle development.

In this study, researchers found that high-dose tryptophan ingestion before symptom onset may be linked to clinical features resembling eosinophilia-myalgia syndrome in patients with eosinophilic fasciitis.

This study observed that tryptophan levels in human hair are higher in males than females, increase with age, and vary with hair color, being highest in grey and white hair.

This review suggests systemic changes in polycystic ovary syndrome may increase the risk of neurodegeneration, potentially linking it to Alzheimer's disease through common pathways affecting tryptophan metabolism.

This study identified a new enzyme, skin l‐tryptophan‐2,3‐dioxygenase, that may play a role in rat hair growth regulation, showing increased activity during peak hair growth periods.

This study reports that six women developed scleroderma while taking L-tryptophan and showed improvement after stopping the supplement and/or starting corticosteroid therapy.

This case report describes a patient with eosinophilia-myalgia syndrome, likely linked to L-tryptophan use, who developed a skin rash characterized by cutaneous mucinosis.

This study reports the development of a novel protocol to purify human TRPV3 ion channels, revealing functional properties and differences in ligand interactions, enabling further structural and functional research.

In this study, the administration of indole-based compounds, particularly L-Tryptophan and Tryptophol, to a PCOS-induced rat model resulted in an increased number of healthy ovarian follicles and a reduction in ovarian cysts compared to untreated rats, suggesting potential therapeutic efficacy.

This study provides evidence that human skin contains genes and enzymes necessary for producing serotonin and melatonin.

This review provides a comprehensive overview of melatonin's physiological roles, effects, and clinical implications, but it does not present new experimental findings.

This review discusses the mechanisms by which sunlight exposure aggravates hair aging and highlights the role of hair pigments in providing photochemical protection, reporting no new results.

This study reports that citrulline, uniquely found in the inner root sheath of hair follicles, can be specifically detected with the carbamido diacetyl reaction, resulting in a bright orange color.

This study found that bleaching, dyeing, and UVA/Vis radiation caused significant cuticle damage and protein loss in both Caucasian and Afro-ethnic hair, highlighting the aggressive nature of these treatments.

This study found that UV radiation exposure increased protein elution and altered protein characteristics in hair fibers, suggesting environmental factors impact hair shaft proteins.

This paper discusses the concept of "coudability," a characteristic of alopecia areata, and provides a historical perspective, but it reports no new clinical results.

This case report illustrates that pellagra can develop in patients with anorexia nervosa without typical signs of severe malnutrition, responding rapidly to nicotinamide and tryptophan therapy.

This study suggests that deficiencies in certain amino acids, like taurine and tryptophan, in artificial milk formulas may contribute to skin and eye problems in Bengal tiger cubs.

This study found that tryptophan fluorescence in natural white hair is significantly weaker than in other unpigmented keratin fibers, possibly due to greater environmental UV exposure or unknown chemical interactions.

This study reports that mutations in human L-PGDS affect the entrance and exit of ligands in its binding cavity, suggesting these residues play a role in ligand interaction processes.

This review article proposes a possible skin-gut-fibrosis axis, suggesting that gut microbial metabolites may influence the development of keloids and hypertrophic scars by affecting immune responses and fibrotic signaling pathways, although direct evidence in skin fibrosis remains limited.

In this study, tresses treated with pH 1.0 acid straightener showed better straightening but more damage to hair properties compared to those treated with pH 2.0.

This study explored non-invasive methods for monitoring low molecular weight biomarkers on the skin's surface, concluding that certain amino acid ratios, such as Phe/Trp, could serve as potential indicators of skin inflammation and cancer.

This article discusses advancements in proteomic and metabolomic analysis techniques for studying hair damage but provides no new clinical results; the authors express interest in applying metabolomics to develop strategies for reducing hair damage from chemical treatments.

This study found that human hair shows progressive damage from UV and gamma radiation exposure, with fluorescence intensity serving as a sensitive measure of radiation-induced changes.

This study found that Platycladus orientalis flavonoids may reduce oxidative damage and slow melanin degradation in AGA-affected hair, improving its quality.

This study found that the acidic hair straightening formulation at pH 1.0 improved hair alignments and straightening effectiveness more than pH 2.0, but it weakened fiber strength and affected hair color and composition.

This study utilized advanced imaging techniques to quantify hair damage and dye uptake dynamics, revealing that compound penetration in hair is influenced by molecule size and lipophilicity.

This article discusses the potential role of melatonin in protecting skin against stress and maintaining homeostasis, based on its local synthesis and various protective functions, but presents no new clinical results.

This study reports that riboflavin may increase enzymatic activity in a GCDH-deficient patient with specific mutations, but doesn't fully normalize urinary organic acid levels.