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Botulinum toxin is effectively used to treat various painful conditions and its therapeutic uses are growing.

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

Mice without certain skin proteins had abnormal skin and hair development.

Low TRPS1 expression in skin and hair cells is linked to hair problems in Trichorhinophalangeal syndrome.

Certain cannabinoids may help increase hair growth and could be useful for treating hair loss.

Finasteride reduces PSA levels by around 40-50% in BPH patients.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

Understanding where cancer cells come from helps create better prevention and treatment methods.

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Stem cell self-renewal is complex and needs more research for full understanding.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

The research identified various cell types in mouse and human teeth, which could help in developing dental regenerative treatments.

Skin fat helps with body temperature control and has other active roles in health.

Mutant mice help researchers understand hair growth and related genetic factors.

Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.

TRH stimulates human hair growth and extends the hair growth phase.

Human hair follicles produce and respond to erythropoietin, helping protect against stress.

The hair follicle is a great model for research to improve hair growth treatments.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Topical JAK inhibitors may help treat some skin conditions but need more research.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Wnt, Eda, and Shh pathways are crucial for different stages of sweat gland development in mice.

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.