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In this study, researchers used cryo-electron microscopy to reveal how the natural compound osthole inhibits TRPV3 channels by binding to specific sites, changing the channel's conformation.

This study found that carvacrol activates the TRPV3 ion channel by binding to a specific pocket formed by the S2-S3 linker, providing insight into its role in skin sensitization and potential for designing specific modulators.

This study found that acid regulation of the TRPV3 channel can inhibit its function from outside the cell while facilitating it from inside, providing insights into skin barrier and disorder mechanisms related to tissue acidosis.

This review explores the role of transient receptor potential vanilloid channels in the pathogenesis of osteoarthritis but reports no new clinical results.

This study suggests that structural changes in the TRPV3 channel are linked to severe skin conditions like Olmsted syndrome, with differences observed between heat-activated and resting states.

This study found that forsythoside A, a compound from Forsythia suspensa, may counteract DHT-induced hair regrowth inhibition by selectively inhibiting TRPV3 channels.

This presentation suggests that the activation of TRPV3 channels by fruit acids and carvacrol contributes to exfoliation and may underlie the skin-resurfacing effects of chemical peels.

This study reports the development of a novel protocol to purify human TRPV3 ion channels, revealing functional properties and differences in ligand interactions, enabling further structural and functional research.

This review discusses current knowledge about the TRPV3 ion channel's role in skin functions and diseases, highlighting its potential as a therapeutic target for pain and itch, though suitable ligands are limited.

This review examined the role of the ion channel TRPV3 in warmth sensation and skin physiology, discussing controversies around its direct contribution to temperature perception, its involvement in skin health, and its potential as a therapeutic target for skin diseases.

This study used cryo-electron microscopy to reveal the structural mechanisms by which TRPV6 and TRPV3 ion channels open, close, and are regulated, providing insights for potential future research.

In this study, TRPV4 channels were found in specific mechanosensory endings in mice skin, suggesting a role in pressure sensation transmitted through A- and C-fibers.

This review discusses the role of the TRPV4 channel in both normal and diseased intestinal functions and suggests that targeting TRPV4 may have clinical significance for treating intestinal diseases due to its involvement in intestinal barrier dysfunction.

This study found that the medication dyclonine has a potent inhibitory effect on the TRPV3 channel, effectively rescuing cell death and alleviating pruritus symptoms in a mouse model with gain-of-function TRPV3 mutations, suggesting potential for treating skin inflammation.

This review discusses the role of transient receptor potential channels in pathological scarification and suggests these channels as potential targets for its prevention and treatment, although it reports no new clinical findings.

This laboratory study concluded that TRPA1 and TRPV1 channels do not play a role in mechanotransduction processes in slowly adapting type II mechanoreceptors in isolated rat sinus hair follicles.

This study found that TRPV3 ion channels on human epidermal keratinocytes suppress cell proliferation, induce cell death, and trigger a proinflammatory response, suggesting a role in cutaneous inflammatory processes.

This study found that inhibiting the TRPV3 channel may significantly promote hair growth and suggests a potential therapeutic approach for hair loss and related skin diseases.

This review discusses the role of the TRPV4 channel in skin physiology and pathology, highlighting its potential as a therapeutic target for skin disorders, but reports no new clinical results.

This review discusses the neurobiology and proposed mechanisms of scalp itch, but it does not report new clinical findings, highlighting the need for further research in this area.

This study examined both human and mouse follicles, finding that cannabinoid and TRPV1 systems independently regulate hair follicle biological functions, impacting hair growth and development.

This review article addresses how the TRPV4 ion channel helps cells respond to mechanical and environmental stimuli, discussing its role in calcium signaling crucial for tissue repair and fibrosis across various organ systems, and highlighting potential therapeutic targets from animal and disease models.

This study found that a gain-of-function mutation in the TRPV3 channel leads to altered hair development in DS-Nh mice by affecting the anagen and telogen phases, highlighting TRPV3's role in hair growth regulation.

In this study, researchers explored various aspects of the TRPV3 ion channel, including its novel mechanosensitivity to shear stress, and identified novel agonists while investigating how repeated stimulation affects TRPV3 activity, but found no evidence of GPCRs sensitizing the channel.

This study found that TRPV3 activation in human sebocytes inhibits lipid synthesis and triggers proinflammatory cytokine expression, suggesting a role in the pathogenesis of dry skin-associated inflammatory dermatoses.

TRPV4 slows hair growth by affecting hair follicle cells.

In this study, calcium imaging in transgenic mice revealed that non-neuronal TRPV4 in the skin enhances afferent signaling during electrical stimulation, suggesting a role for neuroimmune interaction in acupuncture signal initiation.

This study found that activation of the TRPV3 ion channel inhibits human hair growth by affecting hair follicles and outer root sheath keratinocytes.

This review explores the diverse roles of TRPV1, emphasizing its involvement in both pain and non-pain-related functions, but reports no new clinical results.

This study found that TRPV4 activation induced massive exocytosis and cellular changes associated with ferroptosis in melanoma cells, highlighting a potential role for TRPV4 in mediating these processes.