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This study found that TRPA1-deficient mice exhibited normal cold sensitivity but had decreased mechanical response in nociceptors, suggesting TRPA1's role in mechanotransduction.

This review explores the diverse roles of TRPV1, emphasizing its involvement in both pain and non-pain-related functions, but reports no new clinical results.

This study suggests that a position effect disrupting TRPS1 expression may be linked to hypertrichosis in both Ambras syndrome in humans and a similar phenotype in Koa mice.

This study found that the transcription factor Trps1 acts as a novel regulator of the Wnt signaling pathway and early hair follicle progenitors in developing vibrissa follicles in mice.

This review discusses the diverse roles of the TRPS1 gene in regulating cartilage, kidney, and hair follicle development, highlighting its functions and interactions, but provides no new experimental results.

TRPV1 helps regulate hair growth cycles.

This study observed that Trps1 gene expression in mice is precisely regulated in skin development, particularly during hair follicle morphogenesis, with distinct localization patterns in different cell types.

This case report identifies a novel mutation in a patient with trichorhinophalangeal syndrome 1 and reduced TRPS 1 protein expression in hair follicle tissues compared to normal subjects.

TRPM5 is crucial for maintaining hair growth.

In this case report, the authors suggest that a novel enhancer element's translocation near the TRPS1 gene may contribute to the TRPS phenotype, expanding understanding of the syndrome's genetic basis.

In this study, activating TRPV1 nociceptors in mice skin stimulated dormant hair follicles and promoted hair growth through a mechanism involving dermal macrophages, fibroblasts, and neuropeptides, highlighting a new role for nociceptors in tissue recovery after injury.

Reduced TRPS1 leads to increased STAT3 and SOX9 in hair follicles, affecting hair growth.

In a mouse model, this study found that an ethanol-based rosemary extract speeds up wound healing and reduces scarring by activating the TRPA1 nociceptor in sensory neurons, with carnosic acid identified as a key component.

This study found that specific TRPM5 modulators are unlikely to directly affect sebaceous glands, but safe TPPO analogues may provide moderate lipogenic and anti-inflammatory effects beneficial for dry skin conditions.

A new mutation in the TRPS1 gene caused Trichorhinophalangeal syndrome in a 17-year-old, highlighting the need for genetic testing.

This study on mice found that activating TRPML channels with MLSA1 promoted hair regeneration, accelerated hair cycle transition, and influenced human dermal papilla cells to secrete hair growth promoting factors while reducing hair growth inhibitors and oxidative damage.

This case report highlights the discovery of a novel TRPS1 gene mutation in a 17-year-old with TRPS type I, underscoring the diagnostic importance of hair symptoms in congenital hair diseases.

This study found that decreased TRPS1 expression in balding dermal papilla cells may impair their signaling ability, contributing to hair follicle miniaturization in androgenic alopecia.

In this case report, a 20-year-old male with tricho-rhino-phalangeal syndrome was found to have a de novo frameshift mutation in the TRPS1 gene, highlighting the challenges in diagnosing this rare disorder.

This review discusses the role of transient receptor potential channels in pathological scarification and suggests these channels as potential targets for its prevention and treatment, although it reports no new clinical findings.

In this study, researchers identified key genes such as EDNRB2, GPNMB, TRPM1, TYR, and DCT that regulate melanin deposition in the breast muscles of black-boned chickens, contributing to their unique pigmentation during embryonic development.

This study found that TRPV1 activation in human scalp hair follicles inhibited hair shaft elongation, suppressed proliferation, and induced apoptosis, suggesting TRPV1 as a potential target for managing hair growth and epithelial disorders.

Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.

In this study using an animal model, researchers found that PEGL-DOX, unlike DOX, causes Hand-Foot Syndrome due to reactive oxygen species interacting with skin tissue, leading to skin-specific inflammatory responses.

This review discusses the neurobiology and proposed mechanisms of scalp itch, but it does not report new clinical findings, highlighting the need for further research in this area.

This study found that ginsenoside Rg3 significantly inhibited melanogenesis in human melanocytes and B16F10 cells by activating the ERK pathway, suggesting potential as a skin-whitening agent.

This study identified that rose, thyme geraniol, palmarosa, and tolu balsam essential oils activate TRPV1, with citronellol and geraniol as newly recognized agonists.

TRPV4 slows hair growth by affecting hair follicle cells.