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This study suggests that IL-17 may play a more significant role than IFN-γ in the pathogenesis of chronic alopecia areata, with increasing severity linked to Th17 lymphocytes and cytotoxic T lymphocyte infiltration.

This article reviews the role of keratins in epithelial function and structure, discussing their involvement in growth control, organelle functions, and pathomechanisms of disorders, but reports no new clinical results.

This review discusses the complex mechanisms regulating skin immunity to balance host defense with inflammation, but reports no new findings.

This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.

This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.

This study suggests that CD8+ cytotoxic T lymphocytes play a crucial role in the development of alopecia areata, based on observations in rodent models that mimic human autoimmune disease.

This review discusses the role of the immune niche in hair follicle regeneration and its impact on different forms of alopecia, highlighting research gaps and potential therapeutic strategies.

This study found that Ifidancitinib, a JAK1/3 inhibitor, significantly promoted hair regrowth and reduced inflammation in a mouse model of alopecia areata by decreasing pathogenic T cell activity and inducing T cell exhaustion.

This review integrates studies on mouse models and human clinical observations to highlight the role of immune cells in skin development and how their dysregulation leads to skin disorders, suggesting potential therapeutic pathways for skin regeneration.

This review discusses the role of immune cells in the pathogenesis of alopecia areata and highlights emerging immunomodulatory strategies and novel therapeutic targets aimed at offering more effective and durable treatments for this autoimmune hair loss disorder.

This review highlights recent research using single-cell RNA sequencing and machine learning in wound healing, revealing significant insights into fibroblast diversity, immune cell dynamics, and the spatial organization of cells, which may transform therapeutic strategies for chronic wounds, fibrosis, and tissue regeneration.

This study reports that extracellular microvesicles isolated from stimulated dermal fibroblasts enhanced hair follicle growth ex vivo and identified norrin as a novel modulator in hair regeneration processes.

This review discusses the dynamic behavior of immune cells in skin immune responses using intravital imaging in mice and reports no new clinical results.

This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.

This review discusses sex-based differences in immune responses, focusing on genetic, hormonal, and microbiome factors influencing infections like COVID-19, and reports no clinical results.

This review discusses the roles of immune responses and cells in skin health and disease, emphasizing recent insights into their mechanisms and potential therapeutic applications, but presents no new experimental results.

In this study using the C3H/HeJ mouse model of alopecia areata, researchers found that hyperexpanded CD8⁺ T cell clones were sufficient to initiate disease, establishing a causal link between T cell clonality and pathogenicity.

This study provides a framework for understanding different types of alopecias based on immune privilege collapse at specific follicular sites, revealing distinct patterns in immune effector programs and stromal influences depending on the alopecia type.

In this clinical trial, patients with lichen planopilaris treated with the oral TYK2 inhibitor deucravacitinib showed significant improvement in PGA, LPPAI, and Skindex-16 scores over 24 weeks, with transcriptomic analyses indicating decreased inflammatory and immune pathway activity post-treatment.

This review discusses the roles and mechanisms of tissue-resident regulatory T cells in immune regulation and tissue homeostasis, but reports no new experimental results.

This review discusses the mechanisms of skin-associated cell death and their potential role in treating inflammatory skin diseases, but presents no new clinical findings.

This study observed that expanding regulatory T cells in the skin of mice with alopecia areata did not reverse the condition, indicating that additional immunotherapy may be necessary.

This review compiles existing data on frontal fibrosing alopecia and highlights the promise of 5-alpha reductase inhibitors as a treatment option, while noting the need for clarity on its cause and progression.

This study found that anagen stage protein homogenates and specific epitopes from melanogenesis proteins activated CD8 T cells, suggesting alopecia areata is an anagen-specific disease.

This study found that Ift20 is essential for hair follicle stem cell identity and hair regrowth, and it regulates keratinocyte migration during wound healing through focal adhesion integrin recycling, independently of ciliogenesis.

This review synthesizes existing research on the multilayered defense system of the skin, highlighting how physical, chemical, immune, and microbial barriers work together to maintain skin health, with disruptions in one often leading to broader barrier dysfunctions.

This review discusses progress in targeted therapies for vitiligo, focusing on Janus kinase inhibitors and the potential of mesenchymal stem cells, but reports no new clinical results.

This review discusses the regulatory roles of type 2 alarmin cytokines in skin immunity, focusing on their implications in host defense, chronic inflammation, and cancer, but reports no new clinical results.

This review discusses how immune mechanisms contribute to the regeneration and repair of epithelial tissues and highlights their potential role in both disease and therapeutic innovation; it reports no new clinical results.