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Oral isotretinoin may slightly improve acne but increases the risk of side effects like dry lips and skin; more research is needed to understand its full risks and benefits.

9-cis-retinoic acid showed some effectiveness in treating AIDS-related Kaposi sarcoma but had significant side effects at higher doses.

Some skin conditions, like psoriasis and early-onset baldness, may indicate metabolic syndrome, and others are linked to diabetes risk and cardiovascular issues.

THSG from a Chinese plant helps with aging and related diseases.

Metabolic syndrome is more common in people with early-onset androgenic alopecia.

Hormone therapy increases the risk of heart-related issues in transgender women and may affect heart health in transgender men.

The 2023 guideline advises a detailed approach for PCOS, focusing on early detection, lifestyle and medical treatments, and managing health risks.

Retinoids are effective for severe acne and psoriasis but can cause serious side effects and birth defects.

Baricitinib and its combination with lonafarnib improve fat cell formation in certain genetic disorders.

Ethnic Indian women with PCOS often have early symptoms, delayed diagnosis, and need better information and support for treatment and lifestyle management.

The conclusion is that obesity should be managed with a slow, balanced approach to diet and exercise, with medication and surgery as additional options, and education and access to care are important.

Hormone therapy in transgender individuals can increase acne and affect hair growth and loss.

A patient with a nerve disorder died from infection complications after developing insulin resistance from a treatment.

The circadian clock plays a key role in hair growth and its disruption can affect hair regeneration.

The document concludes that managing Dunnigan-Type Familial Partial Lipodystrophy involves treating associated health issues and using medications like metformin and leptin replacement.

Testosterone replacement therapy improved blood sugar and fat levels without raising prostate cancer risk in Japanese men with low testosterone.

There's no significant link between blood fat levels and male pattern baldness.

Finasteride lowers good cholesterol, raises bad fats, and may increase heart disease risk.

Postmenopausal women with hyperandrogenism didn't have better metabolic health even after their testosterone levels became normal.

Brazilian women with PCOS and both menstrual irregularity and high male hormone levels have a higher chance of having metabolic syndrome.

Most adult women with PCOS in Port Harcourt, Nigeria, have high levels of bad fats in their blood, especially younger women.

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

Androgen therapy can help with symptoms like low libido in women, but more research is needed to understand its long-term safety and effects on health.

People with more than 11 skin tags, especially on the thigh, neck, or armpit, may have a higher chance of metabolic syndrome.

People with Lichen Planus, especially with mucosal involvement, are more likely to have Metabolic Syndrome, which increases their risk for heart disease and diabetes.

Women with PCOS have higher xanthine oxidase activity linked to inflammation and heart disease risks.

Men with hair loss have higher BMI, waist size, blood pressure, and are linked to smoking and inactivity.

Early diagnosis and treatment are key to managing health risks in teens with PCOS.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.