97 citations
,
September 2016 in “Reviews in Endocrine and Metabolic Disorders” This review summarizes recent multidisciplinary advances in sebaceous gland research and highlights potential novel therapeutic strategies for skin diseases, but it reports no new clinical results.
71 citations
,
June 2006 in “Human Reproduction” This study found that in young Taiwanese women with PCOS, low sex hormone-binding globulin levels were associated with low HDL cholesterol levels, independent of insulin resistance and obesity.
66 citations
,
January 2017 in “Acta dermato-venereologica” This review suggests that isotretinoin's effects on severe acne and various cancers may result from apoptosis, which might also explain its adverse effects through genetic variability.
47 citations
,
June 2012 in “Genes & Development” This study found that maternal consumption of a western diet in mice led to toxic milk production, causing inflammation and alopecia in nursing neonates due to Toll-like-receptor activation.
42 citations
,
May 2016 in “Annual Review of Cell and Developmental Biology” This review explores the novel roles of white adipose tissue in tissue homeostasis and regeneration, emphasizing its impact on epithelial, muscle, and immune tissues, and reports no new clinical results.
36 citations
,
May 2017 in “The journal of sexual medicine” In this retrospective study, cyproterone acetate treatment in late-pubertal trans-girls was found to be generally safe and led to mild feminizing effects, with more rapid feminization occurring when combined with estrogens.
34 citations
,
July 2010 in “Expert Opinion on Drug Delivery” This review highlights the need for methodologies to understand and quantify drug penetration into hair follicles as significant drug pathways, noting this area lacks comprehensive articles and reports no new results.
23 citations
,
January 2018 in “Elsevier eBooks” This chapter reviews formulation principles for creating cosmetic nanoemulsions and applications targeting skin and hair care, but does not present new experimental results.
19 citations
,
January 2005 in “Paediatrics and Child Health” This review discusses the features and diagnosis of metabolic syndrome in obese children and reports no new findings, highlighting the need for a uniform pediatric definition and early intervention.
18 citations
,
June 2017 in “Proceedings of the National Academy of Sciences of the United States of America” In this mouse study, hair growth defects associated with the Gk5 null allele were partially alleviated by simvastatin treatment, suggesting GK5 plays a key role in skin-specific cholesterol regulation.
13 citations
,
April 2015 in “Human Reproduction” Obese Hispanic women with PCOS are at higher risk for metabolic problems than non-Hispanic white women.
10 citations
,
November 2024 in “Nature Reviews Cardiology” Skin conditions can signal heart issues, highlighting the need for integrated care.
9 citations
,
November 1978 in “Diabetes Care” This study suggests that behavior modification, semistarvation ketogenic regimens, and surgical therapy could be experimental approaches for different degrees of obesity, with their efficacy varying by the degree of weight excess.
6 citations
,
August 2014 in “Toxicologic pathology” This study found that prolonged inhibition of DGAT1 in mice and dogs led to atrophy of sebaceous glands, with mice also experiencing alopecia, suggesting potential skin-related risks for humans using DGAT1 inhibitors.
4 citations
,
November 2023 in “Biological and Pharmaceutical Bulletin” This study found that the BP-3 extract from Boesenbergia rotunda, rich in panduratin A, demonstrated strong anti-adipogenesis and lipolysis effects on preadipocyte cells at non-toxic concentrations, and when formulated into a serum reduced thigh circumference and improved skin firmness in a human trial.
3 citations
,
April 2019 in “Hormone and Metabolic Research” This study found that women with polycystic ovary syndrome have higher insulin resistance and lower serum high-molecular weight adiponectin, which may play a role in the condition's pathogenesis.
2 citations
,
March 2025 in “International Journal of Advanced Science and Engineering” This review highlights that nanoemulsions, especially those with droplet sizes under 200 nm, show promise in pharmaceuticals and cosmetics by improving drug stability, bioavailability, and reducing side effects, with potential applications in CNS diseases, cancer treatments, and skincare products.
1 citations
,
July 2021 in “Research Square (Research Square)” This study found that osteoporosis is common among Sudanese postmenopausal women, who also showed an increased risk for cardiovascular disease, emphasizing the need for enhanced public health education and preventive measures.
1 citations
,
January 2017 in “Tohoku journal of experimental medicine” This study reports the first case of ovarian mature cystic teratoma linked to clinical virilization due to ectopic testosterone production, possibly from overexpression of the enzyme HSD17B5.
1 citations
,
January 2017 in “Spectrum Research Repository (Concordia University)” This study found that young women with PCOS exhibited altered white matter microstructure and reduced cognitive performance compared to matched controls.
July 2026 in “Gazi Medical Journal” This study reported that obese women with polycystic ovary syndrome had higher body fat and insulin resistance, and lower HDL cholesterol compared to non-obese patients and healthy controls.
May 2025 in “Journal of Experimental Pharmacology” This study found that Allium ascalonicum L. extract may improve insulin resistance by increasing insulin tolerance test values and lowering blood glucose levels, though more research is needed to understand its effects on metabolic disorders.
September 2023 in “Journal of pharmacognosy and phytochemistry” This review highlights the medicinal potential and pharmacological activities of the plant Plumbago zeylanica, while emphasizing the critical need for mass propagation methods to address its over-exploitation and support the development of novel herbal medicines.
May 2023 in “Jurnal farmasi sains dan praktis” In this research on cinnamon and virgin coconut oil hair tonics, F2 and F3 demonstrated stable physical properties and mild irritation potential, while formula 1 remained non-irritating but less stable regarding pH and viscosity.
March 2022 in “Research Square (Research Square)” This study found that replacing components with artificial sebum in the modified Leeming and Notman agar medium significantly increased the growth yield of Malassezia restricta.
January 2019 in “Advances in stem cells and their niches” This review outlines the various fibroblast subsets in the skin dermis, their origins, and their influence on epidermal stem cell behavior, highlighting the role of the local dermal niche in stem cell plasticity.
January 2015 in “Durham e-Theses (Durham University)” This study found that glucose starvation and hypoxia are physiological triggers of ER stress in in vitro differentiated adipocytes, rather than high concentrations of saturated fatty acids, cholesterol, or proinflammatory cytokines.
September 2023 in “Clinical, cosmetic and investigational dermatology” In this study, the researchers found that a 28-day topical treatment with a postbiotic ferment complex notably altered the scalp microbiome in women with sensitive scalps, increasing certain bacterial species and decreasing others, while also reportedly alleviating symptoms of sensitive skin syndrome in all participants.
295 citations
,
September 2006 in “Cell Cycle” This review discusses the role of the TOR pathway in aging and suggests that rapamycin could potentially target age-related diseases, but reports no new clinical results.
222 citations
,
January 2014 in “International journal of reproductive medicine” This paper reviews the complex pathophysiology of polycystic ovary syndrome, exploring how hormonal and metabolic disturbances contribute to its symptoms and related health risks, but it presents no new findings.