Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that non-blinded assessors in randomized clinical trials exaggerated the effects of experimental interventions by about 29% compared to blinded assessors, indicating a significant potential for observer bias in treatment evaluations.

This study provides a detailed overview of 1,295 clinical trials related to alcohol dependence registered on ClinicalTrials.gov, highlighting that 59.15% of these trials have been completed, primarily as interventional studies, with most located in North America.

In this randomized, placebo-controlled trial, adults with severe chronic alopecia areata who received deuruxolitinib showed significant hair regrowth compared to placebo over 24 weeks, and the treatment was generally well-tolerated, though long-term effects remain unexamined.

This study examined the preservative and antimicrobial susceptibility of non-fermenting bacilli collected from beauty salon waste in Brazil.

In this study, tofacitinib treatment led to significant hair regrowth in 60% of patients with moderate-to-severe alopecia areata, suggesting potential for JAK inhibitors in treating this condition.

In this double-blind randomized controlled trial, both rosemary extract lotion and 2% ketoconazole lotion were effective for treating scalp seborrheic dermatitis, but rosemary lotion reduced itching more significantly, while ketoconazole was more effective in reducing dandruff.

In this systematic review, significant improvements in clinical severity, patient-reported outcomes, and quality of life were reported for dupilumab compared to placebo in patients with moderate-to-severe atopic dermatitis, prurigo nodularis, and alopecia areata, supporting its efficacy and safety for these dermatological conditions.

Guselkumab significantly improves quality of life for people with moderate to severe psoriasis.

In this pilot study on treating dorsal wrist ganglion, PRP injection showed limited effectiveness at 1-year follow-up compared to aspiration alone, with most PRP-treated patients experiencing ganglion recurrence, suggesting that an RCT would need at least 46 patients per group to further assess PRP's utility.

This study found that patient-reported outcomes were similar between neoadjuvant endocrine therapy and chemotherapy in premenopausal breast cancer patients, but future perspective was significantly better with endocrine therapy.

This open-label study found that oral tofacitinib led to significant hair regrowth in patients with moderate-to-severe alopecia areata, supported by changes in gene expression and T cell dynamics.

In this pilot study, topical latanoprost acid was observed to increase hair count and improve hair follicle structure in women with androgenetic alopecia, with no serious adverse events, suggesting potential for further investigation to confirm its efficacy and safety.

This registry-based analysis observed rapid growth in hair-loss clinical trials between 2015 and 2025, highlighting regional concentration, prevalent therapeutic categories, and diverse outcome reporting while emphasizing the need for standardization and broader representation.

This study analyzed hair-loss clinical trials from 2015 to 2025 and found that, while the number of registrations increased globally, research activity was concentrated in certain regions and varied in therapeutic approaches and outcome specifications.

In this study, topical latanoprost acid applied daily for 6 months increased hair count and improved trichoscopic markers among women with hair loss, suggesting its potential for treating female androgenetic alopecia, particularly at a 0.05% concentration.

This systematic review found that probiotic supplementation improved sleep quality, reduced depressive symptoms, and enhanced aspects of quality of life in women with PCOS, though the findings are limited by a small number of studies and variable methods.

This study found that 15 clinical trials have been registered to investigate the use of mesenchymal stem cell-derived exosomes for treating skin and subcutaneous tissue diseases, particularly alopecia, with a growing global interest and most trials conducted in the United States and China.

In this exploratory randomized controlled trial, participants using a combination of Centella asiatica-derived extracellular vesicles with recombinant growth factors showed significant improvements in hair thickness, density, length, and reduced hair loss and scalp sebum content after 56 days, compared to placebo.

Both 2.5 mg and 5 mg doses of oral minoxidil are effective for hair regrowth in men with hair loss.

This study concluded that platelet-rich plasma is nearly as effective as topical minoxidil for treating androgenetic alopecia, with PRP improving hair density and minoxidil boosting terminal hair count.

5% ET-02 is a more effective and safe treatment for hair loss than current options.

In this study, creatine supplementation over 12 weeks showed no effect on androgen levels or hair follicle health in healthy young males, challenging the belief that creatine causes hair loss.

In this analysis, JAK inhibitors were found to provide clinically meaningful and durable hair regrowth in pediatric alopecia areata, outperforming traditional therapies with a manageable safety profile.

Dermocosmetics significantly reduce itch and skin sensitivity in atopic dermatitis patients.

This study found that among placebo-treated patients in the BRAVE-AA trials, the likelihood of spontaneous hair regrowth in untreated severe alopecia areata was low, with only a small percentage achieving significant scalp, eyebrow, or eyelash hair improvement over 36 weeks.

This systematic review examined 64 randomized controlled clinical trials on regenerative medicine for specific dermatologic disorders, reporting up to 68.4% improvement in androgenetic alopecia and up to 71% improvement in vitiligo among 2888 patients.

This systematic review found that both cellular and acellular stem cell-based therapies are safe and able to improve hair regeneration and density in patients with androgenic alopecia, although some results may be temporary.

This study suggests that psychological interventions such as mindfulness therapy, yoga, cognitive-behavioral therapy, and motivational interviewing may increase the quality of life for women with polycystic ovarian syndrome.

This study found that adults with atopic dermatitis who were treated with baricitinib at doses of 2mg or 4mg experienced significant improvements in work productivity, potentially leading to substantial indirect cost savings for employers over 16 weeks.

This article discusses the potential benefits and challenges of metatrials as a new clinical trial methodology during COVID-19 and reflects on its application in nephrology, but reports no new results.