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This narrative review examined the efficacy and safety of topical tretinoin for various dermatological conditions, finding strong support from robust trials for acne and photoaging, while indicating potential benefits for other uses like melasma and alopecia, yet highlighted the need for more standardized, high-quality trials.

This study found that the retinoic acid derivative Ro 10-9359 cleared psoriasis lesions in over half of the patients, but most experienced side effects, including skin issues and altered liver enzyme levels.

This article reviews various drugs reported to cause alopecia, including cytostatics and anticoagulants, but does not present new research results; it suggests that drug-related hair loss can be difficult to prove.

Retinoids are effective for acne but can cause serious side effects.

This study found that the aromatic retinoic acid derivative Ro 10-9359 provided excellent results in 64% of severe psoriasis patients, especially in those with erythrodermic and pustular types, though relapses and side effects were noted.

This review discusses the various uses of retinoids, derived from vitamin A, in cosmetic and dermatological treatments for conditions like acne, psoriasis, and skin aging. The authors emphasize retinoids' limited use due to their susceptibility to degradation and safety concerns, particularly with retinoic acid.

This study suggests that vitamin A influences the immune response and hair cycle, affecting the progression of alopecia areata in mouse models.

This review discusses the therapeutic effects of vitamins, highlighting risks such as liver damage from prolonged high doses of vitamin A and hypercalcemia from excessive vitamin D, while noting a case of allergic reaction to vitamin B12.

This study discusses the potential of topical retinoids, vitamin A derivatives, to improve treatment outcomes for androgenetic alopecia by promoting hair growth through extending the anagen phase and stimulating follicular activity, offering a promising approach when combined with existing therapies.

This review discusses current concepts on the role of retinoids in keratinization and does not report new clinical results; the authors emphasize the complexity of retinoid effects on skin.

This study identified new dietary ligands for the human vitamin D receptor, including curcumin and gamma-tocotrienol, which may influence its biological functions.

This study found that combining minoxidil with all-trans retinoic acid additively promoted hair growth in vitro by activating certain cell survival pathways and reducing apoptosis markers more effectively than minoxidil alone.

This study found that all-trans and 9-cis retinoic acids increase steroid sulfatase activity in HL60 cells through mechanisms involving RARα/RXR heterodimers and multiple signaling pathways.

This study found that C57BL/6 mice with a diet containing specific levels of vitamin A showed alterations in retinoid metabolism and increased frequency of cicatricial alopecias, suggesting dietary factors may play a role in this condition.

This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.

Topical tretinoin may increase beard hair density.

This study found that the protein hairless acts as both a corepressor and coactivator of the vitamin D receptor, influencing gene transcription in a ligand-selective manner.

This study identifies a mechanism where dsRNA activates TLR3 to induce RA production, promoting hair follicle regeneration in mice and suggesting a potential role in human tissue regeneration.

This study found that using isotretinoin and acitretin was not linked to a higher risk or severity of COVID-19 in patients undergoing systemic retinoid therapy.

This study found that RXRα/RARγ heterodimers are necessary for retinoic acid-induced keratinocyte proliferation in the skin, while normal epidermal maintenance does not require RAR-mediated signaling.

This research indicates that KCED-1 and KCED-2 effectively induce adiponectin production in human subcutaneous fat, which may promote hair growth on the scalp.

This study found that the synthetic retinoid EC23 effectively induces keratinocyte hyperproliferation and enhances hair growth in mice, showing more potency than all-trans retinoic acid.

This review examines the role of nuclear hormone receptors in skin wound repair processes and reports no new clinical results, highlighting the importance of their interaction with skin cells for effective healing.

Some chemicals absorbed through the skin can cause serious health problems.

This article offers strategies for managing acne effectively and safely, emphasizing treatment optimization, patient tailoring, and addressing antimicrobial resistance, but reports no new clinical results.

This review discusses erosive pustular dermatosis of the scalp, highlighting its wide variety of causes and multiple effective treatment options beyond high-potency topical steroids, and reports no new clinical results.

Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.

This report describes a case where a 4-year-old boy with congenital alopecia due to hypohidrotic ectodermal dysplasia experienced significant hair growth after using topical minoxidil.

This review discusses various treatments for adult acne in women, including topical, systemic, and alternative therapies, and reports no new clinical results.

This chapter reviews common cosmetic dermatology techniques but presents no new findings; it discusses treatments like emollients and laser therapy for conditions like photoaged skin and acne scarring.