Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review highlights the possible role of T regulatory cells in the immune-related mechanisms of alopecia areata but reports no new clinical findings.

This study found that regulatory T cells accumulate in hair follicle epithelium via the Cxcr4-Cxcl12 axis, partially influenced by glucocorticoid receptor signaling, promoting hair regeneration; similar mechanisms were observed in human and murine skin.

This review examines the role of Sonic Hedgehog signaling in the maintenance and repair of skin and lung barriers, and its influence on inflammation and atopic diseases; it presents no new clinical findings.

This review explores the crucial role of regulatory T cells in skin wound healing, emphasizing their involvement in balancing immune responses and promoting regeneration. It also discusses Tregs' operations in fibrosis, keloidosis, and scarring, suggesting a potential avenue for novel treatments.

Developing human skin has immune cells with memory-like features.

This study observed that Epigallocatechin-3-gallate (EGCG) can inhibit phosphorylation of STAT1 and reduce a specific subset of immune cells in vitro and ex vivo, suggesting a potential role in maintaining immune privilege in alopecia areata.

This study reviewed the role of probiotics in dermatological disorders and suggests they may help treat or prevent inflammatory skin conditions by modulating the microbiota, potentially reducing the need for steroids and antibiotics, though further research is needed to confirm efficacy and safety.

This review synthesizes existing research on the multilayered defense system of the skin, highlighting how physical, chemical, immune, and microbial barriers work together to maintain skin health, with disruptions in one often leading to broader barrier dysfunctions.

This paper proposes a model integrating regulatory T cells and mesenchymal stem/stromal cells to enhance understanding of peripheral immune tolerance, suggesting their combined roles in immune regulation, autoimmunity pathophysiology, and potential MSC-based therapies.

In this study, Caplan et al. found that treatment with human Tregs expanded from umbilical cord blood may modulate immune responses and improve outcomes in a rodent model of traumatic brain injury.

This study found that blocking LFA-1 signaling completely prevented the development of alopecia areata in C3H/HeJ mice, suggesting that LFA-1 plays a crucial role in the disease's pathogenesis and could be a target for new therapies.

This review explores the role of Tregs in autoimmune skin diseases, transplantation, and skin cancer, and discusses Tregs-based therapies' potential for treating autoimmunity without reporting new experimental results.

In this study, researchers found that a cold atmospheric plasma-activated hydrogel containing interleukin-2 significantly enhanced hair regeneration in a depilated mouse model, promoting larger hair follicles and faster hair growth phase transition, suggesting it as a potential treatment for hair loss.

This study enrolled nine patients to investigate the effects of oral psoralen and ultraviolet A therapy plus oral prednisolone for treating alopecia areata.

This review discusses emerging research areas in alopecia areata pathobiology, highlighting the potential roles of unconventional immune cells and the need for more targeted therapeutic strategies, but reports no new experimental results.

This review discusses recent findings on the mechanisms driving bullous pemphigoid, highlighting epitope spreading and the roles of regulatory T cells, and reports no new experimental results.

This review examines mesenchymal stem cell therapy as a promising alternative for end-stage liver disease, discussing completed clinical trials and highlighting challenges that must be addressed before clinical application.

This review discusses leptin's regulatory roles in the progression of various dermatological diseases and reports no new clinical results, highlighting a complex relationship still under investigation.

This review highlights challenges in developing drugs targeting the Wnt/β-Catenin signaling pathway for cancer due to its complexity and essential roles in normal tissue. It explores targeted protein degradation technology as a promising strategy to overcome these challenges, suggesting potential new avenues for drug development.

This review discusses the role of autophagy in skin cells and its potential implications for treating immune-related skin diseases, reporting no new clinical results.

This review discusses the potential of adipose-derived stem cell extracellular vesicles (ADSC-EVs) in skin regeneration, highlighting mechanisms like inflammation and angiogenesis, but reports no new clinical results; challenges and future prospects are also considered.

This review article summarizes findings that suggest natural products may help treat skin inflammation related to abnormal hormone secretion by the adrenal gland, as they can inhibit inflammation pathways and promote wound healing.

This review summarizes advancements in biomedical engineering for hair follicle regeneration, highlighting strategies like cell transplantation and tissue engineering to reconstruct hair follicles, and discusses both their technical limitations and potential future innovations in regenerative medicine.

This review discusses how immune mechanisms contribute to the regeneration and repair of epithelial tissues and highlights their potential role in both disease and therapeutic innovation; it reports no new clinical results.

The authors discussed that SOCS1 and SOCS3's inhibition of JAKs plays a significant role in the development of JAK inhibitor drugs for skin inflammatory diseases and malignancies.

This review discusses the role of hair follicle stem cells as active signaling centers in skin homeostasis, highlighting recent advancements and reporting no new clinical results.

This review discusses the heterogeneity and plasticity of epithelial stem cells in skin homeostasis, wound healing, and tumorigenesis, reporting no new results but emphasizing the need for further exploration of key regulatory mechanisms.

This study used a probabilistic Boolean network model to explore hair follicle cell fate regulation and predicted that varying TGF-β levels, in coordination with BMP and TNF, can influence either apoptosis or cell proliferation during different follicle growth stages.

This study found that regular yoga practice could benefit women with PCOS by improving hormonal balance, mitochondrial health, oxidative stress, and inflammation, while also reducing depression symptoms, suggesting yoga as a supportive therapy for managing PCOS.

This study suggests that cutaneous lymphadenoma is a distinct benign lymphoepithelial tumor characterized by androgen receptor expression, hair follicle stem cell markers, and common EGFR gene mutations.