22 citations
,
August 2021 in “Frontiers in medicine” This study found that monocytes/macrophages with a pro-inflammatory M1-like phenotype may play a crucial role in the pathogenesis of hidradenitis suppurativa, suggesting potential therapeutic targets.
21 citations
,
September 2003 in “Journal of Clinical Investigation” This paper reports that noggin inhibits BMP-2 and BMP-4 functions by binding and blocking their interaction with the BMP receptor, impacting multiple developmental processes without presenting new research results.
20 citations
,
October 2017 in “Stem Cell Reports” This study found that loss of the ACER1 gene in mice led to increased ceramide levels and progressive hair loss, highlighting ACER1's role in maintaining hair follicle stem cell homeostasis.
19 citations
,
January 2013 in “Frontiers in Neuroanatomy” This study demonstrates a method using intravital imaging to observe sensory hair-cell development and regeneration in zebrafish, which may facilitate assays for drug discovery related to aural function preservation.
16 citations
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March 2021 in “EvoDevo” This study found that zebrafish and sticklebacks, despite differences in their tooth regeneration structures, share a similar genetic program during tooth regeneration, suggesting a conserved "successional dental epithelium" in vertebrates.
16 citations
,
June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that DHHC13 is crucial for hair anchoring and skin barrier function, with its deficiency in Zdhhc13(skc4) mice leading to cyclic alopecia and skin abnormalities due to cornifelin deficiencies.
16 citations
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August 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that MED1 plays a role in maintaining keratinocyte quiescence and hair follicle stem cell populations, as its absence in mice led to increased keratinocyte proliferation and reduced stem cell numbers.
15 citations
,
October 2020 in “Journal of Nanomaterials” This review discusses the potential of strontium-containing electrospun nanofibers for bone tissue engineering, outlining their effects on various cell types and highlighting current research challenges and future perspectives in the field.
14 citations
,
March 2016 in “Mechanisms of Development” This study found that BNC2 is critical for hair follicle regeneration and other developmental processes, as Bnc2−/− mice exhibit incomplete hair follicle development and developmental defects, and BNC1 cannot substitute for BNC2.
12 citations
,
April 2023 in “Pharmaceutics” This review covers the current and potential medical uses of semifluorinated alkanes, including applications in eye surgery, drug delivery, and oxygen transport.
9 citations
,
January 2025 in “Droplet” This review explores recent advancements in precise cell manipulation technologies, detailing the status, principles, benefits, limitations, and future potential of methods like single-cell manipulation and 3D bioprinting for cells and tissue engineering.
9 citations
,
March 2019 in “Molecular & cellular proteomics” In this study, around 1% of proteins in skin fibroblasts significantly changed in response to reductive stress, affecting collagens and MAPK signaling pathways.
8 citations
,
September 2021 in “EMBO Molecular Medicine” This study found that a 5-mer peptide called P5 promotes hair growth by activating adiponectin receptor 1, suggesting its potential use as a topical treatment for alopecia.
7 citations
,
May 2025 in “Journal of Biomedical Science” This study found that KRT6A expression increases after epidermal barrier disruption, worsening skin inflammation in disease conditions, and suggests that targeting KRT6A could offer a new treatment approach for inflammatory skin diseases linked to epidermal dysfunction.
7 citations
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May 2024 in “Gels” This study evaluated a new collagen and tannic acid hydrogel in rat liver and heart bleeding models, finding it reduced blood loss and hemostatic time compared to commercial products, with benefits such as enhanced biodegradability and potential for clinical use.
7 citations
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February 2024 in “ACS Applied Materials & Interfaces” This study found that PEGylated Ag₂S-ZnS@TGA-AA heteronanostructures, activated by light exposure, showed synergistic antibacterial effects against multidrug-resistant bacteria, significantly accelerating the healing of MRSA-infected wounds in comparison to untreated wounds.
6 citations
,
July 2025 in “Advanced Materials” This review discusses cell membrane-coated scaffolds in tissue engineering, emphasizing their potential to enhance therapeutic outcomes in regenerative medicine and reporting no new experimental results.
5 citations
,
December 2023 in “Current Biology” A feedback loop between LRH and RSL4 controls root hair growth in Arabidopsis.
5 citations
,
October 2022 in “Frontiers in bioengineering and biotechnology” Ro stress hindered ginseng root growth and ginsenoside production, but increased certain hormones and affected gene regulation related to plant growth and stress responses.
5 citations
,
November 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that inhibiting Wnt/β-catenin signaling disrupted hemidesmosome organization in keratinocytes, suggesting potential therapeutic targets for HD-defective diseases like epidermolysis bullosa.
4 citations
,
August 2025 in “Frontiers in Immunology” This review explores how mesenchymal stem cells and their extracellular vesicles may treat various skin diseases by modulating immune responses and promoting healing, though further clinical trials are needed to confirm their safety and efficacy in practice.
4 citations
,
April 2024 in “Animals” This study reported allergic dermatitis in Brazilian donkeys linked to Culicoides insect bites, characterized by severe itching and skin lesions. The potential treatment with copaiba oil and multivitamin emulsion was explored, revealing its promise for managing this condition.
4 citations
,
October 2021 in “Journal of Cellular and Molecular Medicine” This study observed that mature neutrophils and their extracellular traps inhibit wound-induced hair follicle neogenesis in mice, despite being stimulated by pro-regenerative cues.
2 citations
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April 2025 in “Biomedicine & Pharmacotherapy” This research reports that copper-quercetin complexes show strong potential in antioxidation and cancer therapy, while their effects on specific cell death pathways warrant further investigation.
2 citations
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October 2023 in “Philosophical Transactions of the Royal Society B Biological Sciences” This study identified novel isoforms of the PADI2 and PADI3 proteins, showing that PADI2β inhibits oligodendrocyte differentiation, possibly by opposing the effect of canonical PADI2, while PADI3β modulates the activity of PADI3α, suggesting new regulatory mechanisms of citrullination in tissue development.
1 citations
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January 2025 in “IntechOpen eBooks” This source outlines the development of a comprehensive system for evaluating the safety and efficacy of cosmetics in China compared to established practices in Europe and the U.S., highlighting factors like AI technologies and specific product categories such as anti-aging and sun protection.
1 citations
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July 2023 in “Communications biology” In this study, researchers found that deleting Med1, a key epigenetic regulator in dental epithelia, led to hair growth on mouse incisors by altering enhancer landscapes and causing a switch from dental to hair lineage transcription programs.
1 citations
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December 2022 in “Plants” This study suggests that CSLD1 is key to nitrogen-dependent root hair elongation and regulation of AMT1;2 expression in rice roots.
1 citations
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October 2022 in “Biomedicines” This study found that Prdm1 is crucial for whisker development in mice, affecting multiple signaling pathways and possibly playing a role in primates' evolutionary loss of vibrissae.
December 2025 in “The Journal of Cell Biology” This study found that keratin 15 lacks the ability to sequester YAP1 in keratinocytes effectively, unlike keratin 14, and suggests that a higher K15:K14 ratio may promote a progenitor state and inhibit differentiation in epidermal keratinocytes.