research A Transient Dermal Niche and Dual Epidermal Programs Underlie Sweat Gland Development
Sweat gland development involves two unique skin cell programs and a temporary skin environment.
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research Intrinsic Activation of Cell Growth and Differentiation in Ex Vivo Cultured Human Hair Follicles by a Transient Endogenous Production of ROS
Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.
research Polymeric Nanoparticles-Based Topical Delivery Systems for the Treatment of Dermatological Diseases
Polymeric nanoparticles show promise for treating skin diseases.
research Genetic Alteration of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase Subunit Expression Affects Calcium Currents and Beta-Endorphin Release in AtT-20 Clonal Pituitary Cells
Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.
research Loss-Of-Function of Endothelin Receptor Type A Results in Oro-Oto-Cardiac Syndrome
A mutation in the EDNRA gene causes Oro-Oto-Cardiac syndrome, affecting face and heart development.
research Mesothelial Stem Cells and Stromal Vascular Fraction for Skin Rejuvenation
Adipose-derived stem cells show potential for skin rejuvenation and wound healing but require more research to overcome challenges and ensure safety.
research DNA Microarray and Bioinformatic Analysis Reveals the Potential of Whale Oil in Enhancing Hair Growth in a C57BL/6 Mice Dorsal Skin Model
Whale oil significantly promotes hair growth and may be a safe, effective alternative to minoxidil.
research Micro-Current Stimulation Has Potential Effects of Hair Growth Promotion on Human Hair Follicle-Derived Papilla Cells and Animal Model
Micro-current stimulation may promote hair growth more effectively than standard treatments.
research Low-Dose Oral Minoxidil for Alopecia: A Comprehensive Review
Low-dose oral minoxidil may help treat hair loss but is not FDA-approved and can cause side effects like unwanted hair growth and heart issues.
research Finasteride Interferes with Prostaglandin-Induced CatSper Signalling in Human Sperm
Finasteride may affect male fertility by interfering with specific sperm signaling.
research CBL1-CIPK26-Mediated Phosphorylation Enhances Activity of the NADPH Oxidase RBOHC, but Is Dispensable for Root Hair Growth
A specific protein complex increases the activity of a plant enzyme, but this action is not required for plant root hair growth.
research Potassium Channel Openers: Pharmacological and Clinical Aspects
Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.
research Potassium Channel Therapeutics at the Bedside
Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.
research Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease
Hair follicles have a more inactive cell cycle than other skin cells, which may help develop targeted therapies for skin diseases and cancer.
research Highlights From the Literature
Apoptosis, not oxidative stress, is linked to aging in mice with mtDNA mutations.
research Repurposing Steroidogenesis Inhibitors for the Therapy of Neuropsychiatric Disorders: Promises and Caveats
Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.
research Melatonin Membrane Receptors in Peripheral Tissues: Distribution and Functions
Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.
research Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment
Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.
research Cellular Senescence and Aging in Myotonic Dystrophy
Myotonic Dystrophy may age cells faster, and drugs that target aging could be potential treatments.
research Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options
The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.
research Female Pattern Hair Loss: Therapeutic Update
Topical minoxidil is the best-supported treatment for female hair loss, but personalized plans are needed.
research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth
Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
research Gene Therapy: Recent Advances and Applications in Dermatology
Gene therapy shows promise for treating skin disorders and cancer, but faces technical challenges.
research Expression and Functional Relevance of Melatonin Receptors in Hair Follicle Biology
Melatonin receptors in hair follicles help regulate hair growth and could treat hair loss.
research Characterization of CD4+ Stem Cells of the Skin and Their Role in Skin Homeostasis and Tumorigenesis
CD4+ skin cells may be precursors to basal cell carcinoma.
research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia
PGD2 stops hair growth and is higher in bald men with AGA.
research Frontiers in Alopecia Areata Pathobiology Research
The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.
research ESGCT and FSGT Collaborative Congress Helsinki, Finland September 17–20, 2015 Abstracts
The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.
research The Pharmacology of Regenerative Medicine
Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.
research Past and Future Strategies for GPCR Deorphanization
Finding functions for unknown GPCRs is hard but key for making new drugs.