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This scoping review aims to explore the impact of hormone therapy on the laboratory profiles of transgender people, identify evidence, and highlight literature gaps, particularly in developing countries.

In this study, the researchers reported that altering β-catenin signaling in a transgenic mouse model led to changes in skin cell fate, notably converting hair follicle cells into epidermal cells and forming cysts instead of follicles.

This study found that in a transgenic mouse model, a modified form of β-catenin inhibited normal hair follicle development and promoted epidermal cyst formation, revealing distinct effects on Wnt signaling.

This publication reviews the World Professional Association for Transgender Health's Standards of Care for supporting transgender and gender nonconforming people, with adjustments needed for diverse global contexts and no new clinical results.

This review discusses the effects of hormonal treatments on the physical and mental health of transgender individuals, reporting significant reductions in mental health issues following treatment, but calls for more research on long-term and nonbinary outcomes.

This review discusses the effects of testosterone therapy for transgender men, noting desired outcomes and potential risks, but reports no new research findings; the authors highlight a lack of high-quality data due to various study limitations.

This review discusses the creation of transgender-specific guidelines by WPATH and the Endocrine Society, based mostly on clinical experience, and reports no new results.

This review discusses the therapeutic options for transgender individuals, including hormonal and surgical treatments, and reports no new clinical results; the authors highlight the need for more research on long-term effects.

This article reviews the care of transgender patients, encompassing diagnosis, treatment options, and challenges in health care access, but does not present new research findings; the authors emphasize the critical role of providers in addressing transgender health needs.

This commentary discusses the feasibility and challenges of uterine transplantation for transgender women, emphasizing anatomical, hormonal, and ethical considerations without reporting new clinical results.

Hormonal treatment in transgender women reduces semen quality, but stopping treatment may improve it.

This review offers transgender hormone treatment guidelines to assist healthcare providers in improving transgender patients' access to and outcomes of medical care, but it reports no new clinical results.

This review discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy and reports no new clinical results, emphasizing the need for tailored guidelines.

This review discusses the unique dermatologic needs of transgender individuals during transitioning and emphasizes the importance of accommodating care in medical settings; it reports no new clinical results.

This review discusses the unique healthcare needs and disparities faced by transgender individuals, highlighting the importance of cultural competency and skills in providers, but reports no new clinical findings.

This review discusses skin diseases in transgender patients receiving gender-affirming hormone therapy and procedures, highlighting unique conditions and the underdiagnosis that affects their quality of life and mental health.

This review discusses the dermatologic care of transgender individuals and highlights the need for more quantitative research to improve clinical understanding and support future studies.

This review discusses lesser-known concerns in transgender dermatology, including neovaginal issues, neoplastic and autoimmune conditions, and the effects of unapproved injectable substances, but reports no new clinical findings.

This review discusses the dermatologic issues faced by transgender patients, including impacts of hormonal therapy on skin, but reports no new clinical findings.

In this study, testosterone use in gender-minority patients was associated with significantly worse androgenetic alopecia severity scores, while feminizing hormone therapy did not significantly change hair loss severity.

In this systematic review, an increase in hemoglobin and hematocrit was associated with testosterone therapy, especially within the first year, and factors like serum testosterone levels and therapy specifics were linked to erythrocytosis development, highlighting the need for further research to guide clinical practice.

This review discusses the challenges and considerations in managing transgender patients in critical care, noting gaps in current medical curricula and suggesting improvements in education.

This study reported that facial hair is a crucial aspect of gender identity and transition for transmen, with a majority dissatisfied with their current facial hair despite testosterone therapy.

This study found that care for transgender Veterans at VANCHCS could benefit from a more consistent, team-based approach to therapy.

This study identified common dermatological issues and procedures among transgender individuals in India, highlighting insufficient access to dermatological services and distinct cosmetic concerns related to hormone and surgery changes during transition.

In this study of transgender and gender-diverse adults, the researchers observed that one-third of those on psychotropic medications within two years of starting hormone therapy experienced psychotropic polypharmacy, with a significantly higher likelihood of potential drug-hormone interactions in this group.

This review discusses treatment options for androgenetic alopecia in transgender and gender-diverse patients, highlighting first-line treatments like topical minoxidil and finasteride, but reports no new clinical results.

This study indicates that transgender men undergoing testosterone therapy may encounter skin issues like acne and hair thinning, which can be addressed with a collaborative approach involving both dermatologists and endocrinologists.

This study found that transgender men undergoing testosterone therapy may experience skin changes such as acne and androgenic hair loss, which can be managed with a collaborative approach involving both dermatologists and endocrinologists.