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Testosterone treatment effectively causes male physical development in transgender male adolescents but may lead to side effects like acne, higher BMI and blood pressure, lower good cholesterol, and decreased bone density.

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

Orthognathic surgeons play a key role in modifying masculine facial features to be more feminine, often improving transgender women's quality of life.

Beard hair transplantation is generally satisfying, requires 250-800 grafts, uses FUE to avoid scars, needs careful planning, has some risks, and hair regrowth starts after 4-6 months.

A 14-year-old girl with no menstrual period was diagnosed with Swyer Syndrome and treated for a related cancer risk.

Certain drugs can worsen hair loss in people prone to androgenetic alopecia.

Spironolactone does not increase cancer risk and may lower prostate cancer risk, but more research is needed.

Older adults still engage in sexual activities but face challenges like health issues and lack of professional support, highlighting the need for better healthcare provider education and research on sexual fulfillment in old age.

The surgical technique of scalp advancement and pretrichial brow lift shortens the forehead and lifts brows, is good for women and transgender women with high foreheads, but not recommended for men and has some risks.

Nonandrogenic factors like oxidative stress and microinflammation are important in hair loss progression.

People with androgenetic alopecia have a higher risk of metabolic syndrome.

Significant facial gender transformation requires surgery, not nonsurgical methods.

BMI is not a significant predictor of complications after gender-affirming penile inversion vaginoplasty.

Testosterone replacement therapy helps manage deficiency and has various methods, but requires careful monitoring to avoid side effects.

Using umbilical cord stem cells can help create hair-growing tissues more affordably.

The hCG diet and testosterone therapy can cause hair loss in some people.

Finasteride and dutasteride do not significantly change beard thickness in men.

Proper planning and technique in upper-face feminization surgery are crucial to avoid complications and revisions.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Microneedling with platelet-rich plasma and minoxidil improves hair growth more than just minoxidil in men with hair loss.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Fully regenerating human hair follicles not yet achieved.

Syphilis can cause unusual symptoms like hair loss and joint pain, but treatment is effective.

Spironolactone is safe for treating female hair loss, but the safety of other drugs is uncertain.

The document concludes that hormone therapy is essential for treating gender dysphoria, with specific drugs and monitoring protocols recommended for safety and effectiveness.

The document recommends a multidisciplinary approach and experience sharing to advance facial feminization surgery as a medical field.

Exogenous testosterone use may be linked to developing hidradenitis suppurativa.

Women may need different blood pressure guidelines than men for heart disease prevention.