November 2025 in “PLoS ONE” This study found that synthetic RNA and DNA trigger significant increases in certain chemokines in human keratinocytes, predominantly via NF-κB activation, without evidence of alternative splicing, suggesting other regulatory pathways may be involved.
April 2025 in “Materials Today Bio” In this study, researchers demonstrated that self-assembled gold nanoclusters with aptamers effectively deliver anti-NFκB aptamer drugs to inhibit hair follicle regeneration while being non-toxic to normal cells, offering a targeted treatment for hypertrichosis.
January 2017 in “Murdoch Research Repository (Murdoch University)” This study identified the novel genetic variant rs143321413 within the EEF2K gene, which may play a role in the development of polycystic ovary syndrome.
January 2016 in “Munich Personal RePEc Archive (Ludwig Maximilian University of Munich)” This study demonstrated that a light-activated RNAi approach using hollow gold nanoshells effectively targets human prostate cancer cells with reduced off-target toxicity and material use compared to standard methods.
February 2014 in “PubMed” This study reports that high-purity rHFSCs with strong proliferation and high VEGF165 expression can be efficiently obtained, facilitating tissue engineering applications like artificial hair follicles and skin construction.
March 2010 in “Ejc Supplements” This article discusses the paradoxical effects of valproic acid on hair, reporting both drug-induced hair loss and the potential for hair growth when used topically, but presents no original research findings.
February 2023 in “Materials today bio” In this study, researchers developed a promising transdermal agent using Triton X-100-modified polyethyleneimine that successfully delivered genetic material to hair follicle cells in mice, potentially alleviating hair loss due to androgenetic alopecia by promoting cell proliferation and inhibiting apoptosis.
612 citations
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February 2004 in “Nature” This study found that the OXI1 gene in Arabidopsis thaliana is vital for activating key protein kinases and is necessary for oxidative burst signal responses like pathogen resistance and root hair growth.
449 citations
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December 2005 in “The Plant Cell” This study found that the BIK1 gene in Arabidopsis thaliana modulates defense responses to pathogens and is essential for normal root growth and development.
223 citations
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January 2014 in “International Journal of Molecular Sciences” This article reviews the complex signaling pathways between epithelial and mesenchymal cells crucial for hair follicle morphogenesis, highlighting the Wnt pathway's role as a master regulator without reporting new experimental findings.
147 citations
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August 2005 in “The Plant Cell” This study identified a key Arabidopsis thaliana gene, TIP1, whose product is involved in S-acylation crucial for normal plant cell growth, particularly affecting root hair development.
111 citations
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June 2002 in “The EMBO Journal” This study found that overexpression of Smad7 in transgenic mice led to severe alterations in multiple epithelial tissues, resulting in early death after birth.
109 citations
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January 1997 in “Journal of Experimental Botany” This paper discusses the cellular and molecular processes involved in root hair growth in higher plants, focusing on cytological phenomena and the effects of growth regulators and mutations, but reports no new experimental findings.
102 citations
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August 2008 in “Genes & Development” This study found that laminin-511 is crucial for hair morphogenesis in mice, as it influences primary cilia formation and dermal papilla maintenance through noggin and sonic hedgehog signaling.
90 citations
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August 2004 in “Physiological Genomics” This study found that coculturing human hair follicle keratinocyte stem cells with dermal papilla cells increased expression of the hair-specific keratin 6hf gene, which requires β-catenin/lef-1 signaling for hair differentiation.
90 citations
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October 1996 in “Dermatologic Clinics” This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.
58 citations
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November 2020 in “International Journal of Molecular Sciences” This review discusses the relationship between SHBG, NAFLD, and PCOS and reports no new clinical results; the authors highlight low hepatic SHBG production as potentially significant in PCOS pathogenesis.
52 citations
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May 1997 in “Journal of Biological Chemistry” This study suggests that polyamines regulate CK2 enzyme activity and its subcellular distribution, as demonstrated in mouse models and cell cultures with elevated levels of ornithine decarboxylase.
33 citations
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January 2001 in “Critical care clinics” This article reviews the roles and synthesis of essential long-chain fatty acids in the body and reports no new research findings; it emphasizes the importance of dietary sources for these lipids.
29 citations
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March 2022 in “Biomedicines” This review discusses recent findings on cellular antioxidant responses to oxidative stress and their implications for treating various human diseases but reports no new clinical results.
23 citations
,
February 2015 in “International Journal of Molecular Sciences” This study found that colchicine treatment significantly reduced hair fiber elongation in cultured hair follicles and altered protein expression and activity in dermal papilla cells, suggesting a role for the ubiquitin-proteasome system in its effects.
15 citations
,
April 2016 in “Hormones” This review summarizes the clinical features and molecular causes of Primary Generalized Glucocorticoid Resistance, highlighting new findings from the characterization of mutations in the NR3C1 gene, but reports no new experimental results.
14 citations
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March 2021 in “Actas Dermo-Sifiliográficas” This review discusses the JAK/STAT signaling pathway's role in immune-mediated skin diseases and examines the efficacy and safety of JAK inhibitors for treating vitiligo and alopecia areata, but reports no new clinical results.
13 citations
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July 2024 in “BMC Genomics” In this study, researchers found that single SNPs have a small genetic effect on phenotypes in Inner Mongolia cashmere goats, and constructing haplotypes from associated SNPs may uncover complex variations in cashmere traits, aiding genomics and breeding efforts.
9 citations
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June 2024 in “BMC Genomics” This study identified genetic variations associated with black and white wool color in Gangba sheep, enhancing understanding of wool color genetics and aiding selective breeding for specific wool colors in Tibetan sheep.
7 citations
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August 2017 in “PloS one” This study found that NIH hairless mice exhibit abnormalities in hair growth and immune-related pathways, with Pik3r1 and Pik3r3 identified as key genes for further investigation.
4 citations
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November 2014 The skin protects the body, regulates temperature, senses touch, and makes vitamin D.
2 citations
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March 2025 in “Nanoenergy Advances” This review examines recent advances in bioelectronic nanogenerators for anti-cancer therapy, highlighting various transducing strategies such as photodynamic therapy and electrical stimulation, while also discussing the potential mechanisms for tissue repair and the challenges that lie ahead.
2 citations
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September 2009 in “Pigment Cell & Melanoma Research” This study found that non-cutaneous melanocytes in mice are less sensitive to Kit signaling compared to cutaneous melanocytes, showing dependence on ET3 and HGF signaling.
In this study, calcium imaging in transgenic mice revealed that non-neuronal TRPV4 in the skin enhances afferent signaling during electrical stimulation, suggesting a role for neuroimmune interaction in acupuncture signal initiation.