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Neural progenitor cell-derived nanovesicles help hair growth by activating a key signaling pathway.

UV radiation may cause DNA changes in skin, certain UVB therapy helps psoriasis, a new gene mutation is linked to mild piebaldism, different immune cells affect psoriasis, a drug promotes hair growth, and some cancer drugs could treat skin barrier issues.

Researchers found key regions in the mouse hairless gene that control its activity in skin and brain cells, affecting hair follicle function.

Astrotactin2 affects hair follicle orientation and skin cell polarity.

MPZL3 is crucial for seborrheic dermatitis development.

FOXC1 boosts SFRP1 in hair loss, suggesting new treatments.

Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Low-level Laser Therapy may help reduce inflammation, pain, and aid healing, but more research is needed to confirm its effectiveness and establish standard treatment guidelines.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

Stromal stem cells may help heal wounds by becoming structural cells or affecting the immune system, but more research is needed to understand how.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

Oxidative stress affects hair loss in men with androgenetic alopecia.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.