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GlossarySignaling Pathways (Signal Transduction Pathways)

series of molecular interactions transmitting signals within cells

Signaling pathways, also known as signal transduction pathways or cell signaling pathways, are a series of molecular interactions that transmit signals from a cell's exterior to its interior, leading to a specific cellular response. These pathways involve receptors, enzymes, and other proteins that work together to regulate various biological processes, such as cell growth, differentiation, and apoptosis. Understanding these pathways is crucial for developing treatments for conditions like cancer and alopecia, where signaling disruptions can lead to disease.

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research Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

1 citations, May 2017 in “InTech eBooks”

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

research Supplemental Information: Androgenic Alopecia – Crosstalk Between Cell Signal Transduction Pathways

March 2017

research MicroRNA Control of Signal Transduction

1066 citations, March 2010 in “Nature Reviews Molecular Cell Biology”

MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.

Differential Gene Expression Analysis Between Anagen and Telogen of Capra Hircus Skin Based on the De Novo Assembled Transcriptome Sequence

research Differential Gene Expression Analysis Between Anagen and Telogen of Capra Hircus Skin Based on the De Novo Assembled Transcriptome Sequence

31 citations, March 2013 in “Gene”

Signaling pathways are crucial for hair growth in goats.

research A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A

124 citations, August 1994 in “Journal of Investigative Dermatology”

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

research Hair Follicle Culture

January 2012 in “Methods in pharmacology and toxicology”

Hair follicle culture helps study hair growth but has limitations in modeling the full hair cycle.

research Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production

450 citations, January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color is determined by melanin produced and transferred in hair follicles.

research Exosomes as a Roadmap from Research to Clinical Development in the Management of Skin Diseases

May 2024 in “Journal of drug delivery science and technology”

Exosomes show promise for treating skin diseases and improving skin regeneration.

research Lymphatic Vessel: Origin, Heterogeneity, Biological Functions, and Therapeutic Targets

3 citations, January 2024 in “Signal transduction and targeted therapy”

Lymphatic vessels are essential for health and can be targeted to treat various diseases.

research The JAK/STAT Signaling Pathway: From Bench to Clinic

489 citations, November 2021 in “Signal Transduction and Targeted Therapy”

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

research NF-κB in Biology and Targeted Therapy: New Insights and Translational Implications

1 citations, March 2024 in “Signal transduction and targeted therapy”

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Graphene Oxide and Indole-3-Acetic Acid Cotreatment Regulates the Root Growth of Brassica Napus L. via Multiple Phytohormone Pathways

research Graphene Oxide and Indole-3-Acetic Acid Cotreatment Regulates the Root Growth of Brassica Napus L. via Multiple Phytohormone Pathways

34 citations, March 2020 in “BMC plant biology”

Graphene oxide and indole-3-acetic acid together inhibit root growth in Brassica napus L. by affecting multiple plant hormone pathways.

research Signaling Pathways and Targeted Therapeutic Strategies for Polycystic Ovary Syndrome

October 2023 in “Frontiers in endocrinology”

Effective PCOS treatments require targeting specific signaling pathways.

research Nitric Oxide Signal Transduction and Its Role in Skin Sensitization

1 citations, June 2023 in “Biomolecules & therapeutics”

Nitric oxide is important for skin functions and both helps protect against and contributes to skin inflammation and sensitization.

research Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair

24 citations, May 2016 in “Stem Cell Reviews and Reports”

The document concludes that understanding how adult stem and progenitor cells move is crucial for tissue repair and developing cell therapies.

research Co-Opting Developmental Signaling Pathways to Promote Wound Healing

1 citations, January 2018 in “Recent clinical techniques, results, and research in wounds”

Using developmental signaling pathways could improve adult wound healing by mimicking scarless embryonic healing.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

24 citations, September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Lactoferrin Promotes Hair Growth in Mice and Increases Dermal Papilla Cell Proliferation Through Erk/Akt and Wnt Signaling Pathways

research Lactoferrin Promotes Hair Growth in Mice and Increases Dermal Papilla Cell Proliferation Through Erk/Akt and Wnt Signaling Pathways

18 citations, April 2019 in “Archives of Dermatological Research”

Lactoferrin helps mice grow hair by increasing cell growth and hair follicle development.

research The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration

2 citations, November 2023 in “Biomolecules”

WNT signaling is crucial for skin development and healing.

research Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells

105 citations, October 2017 in “Stem cells”

Wnt signaling is crucial for skin development and hair growth.

research A Screen for Key Genes and Pathways Involved in High-Quality Brush Hair in the Yangtze River Delta White Goat

18 citations, January 2017 in “PloS one”

Certain genes and pathways are crucial for high-quality brush hair in Yangtze River Delta White Goats.

Phosphatidic Acid Has Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

research Phosphatidic Acid Has Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

46 citations, August 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

Phosphatidic acid may help hair grow by affecting cell growth pathways.

research Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways

3 citations, July 2023 in “International journal of molecular sciences”

Stress may contribute to hair loss in alopecia areata by affecting immune responses and cell death in hair follicles.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

28 citations, October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

research A Computationally Inferred Regulatory Heart Aging Model Including Post-Transcriptional Regulations

1 citations, December 2016

Researchers created a model to understand heart aging, highlighting key genes and pathways, and suggesting miR-208a as a potential heart attack biomarker.

research Network Pharmacology Reveals Curcuma Aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia

July 2024 in “Biology”

Curcuma aeruginosa Roxb. may help treat hair loss by affecting specific biological pathways.

research Molecular Regulation of Melanocyte Senescence

85 citations, July 2002 in “Pigment Cell Research”

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.