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Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Air pollution (PM10) increases skin inflammation and aging by reducing collagen and may trigger a repair response in skin cells.

Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.

The conclusion is that published guidelines are improving transgender medical care, but more research and education in transgender medicine are needed.

Liposomes can safely and effectively deliver substances to mouse hair follicles, potentially useful for human hair treatments.

The method effectively detects banned substances in urine for sports antidoping.

DHEA did not improve sexual function, well-being, or menopausal symptoms in postmenopausal women with low libido but caused side effects like acne and increased facial hair.

Taking DHEA for a year is generally safe for postmenopausal women but may cause acne and more facial hair without improving metabolism or aging.

Botulinum toxin has potential for treating various skin conditions and improving wound healing.

Stress from being transgender is linked to higher blood pressure at night and more inflammation, which may affect heart health.

Premature ovarian insufficiency (POI) can harm women's sexual health, and they may benefit from hormone therapy and counseling.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Azelaic acid and anthralin are similarly effective for treating patchy hair loss.

Chitosan/LiCl composite scaffolds help heal deep skin wounds better.

Finasteride can cause sexual problems and depression in young men.

Androgens affect bone and fat cell development differently based on the cells' embryonic origin.

Heparin and protamine are promising in tissue repair and organ regeneration, including skin and hair.

Nandrolone might increase muscle mass with fewer side effects than testosterone but could cause erectile dysfunction and needs more research.

Young women with nonclassic congenital adrenal hyperplasia may experience worse sexual function and mild depression compared to healthy women.

A small number of premenopausal female blood donors had high prolactin levels, often due to stress, and retesting is recommended to prevent misdiagnosis.

Minoxidil can cause deadly skin reaction; monitor patients closely.

New scalp surgery technique results in thinner, less visible scars.

Mitochondrial therapy and platelet-rich plasma therapy both stimulated hair regrowth in aging mice, with mitochondrial therapy showing similar effectiveness to plasma therapy.

Low-level laser therapy using near-infrared light may help heart conditions and promote healing by releasing nitric oxide.

LLLT devices for hair loss need more research to define proper guidelines.

Most women with hirsutism have it because of PCOS, and they need long-term treatment including medication and hair removal to improve their condition.

Adding platelet-rich plasma improves hair density and thickness in androgenetic alopecia.

The document concludes that early and personalized treatment for PCOS in adolescents is crucial to manage symptoms and prevent long-term health issues.

Pre-operative hormone treatment for hypospadias surgery might improve outcomes, but more research is needed to confirm.