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In this study, the researchers identified the SPEF2 and PRLR genes as potential candidates associated with feather rate phenotypes in Shouguang chickens through combined genome-wide association and differential expression analyses.

In this study, researchers used spatial transcriptomics to identify increased expression of genes linked to extracellular matrix organization and epithelial–mesenchymal transition in the progenitor cell regions of hair follicles in androgenetic alopecia patients, suggesting a possible role in progenitor cell loss and fibrogenic microenvironment development.

In this study, researchers observed distinct aging signatures in mouse keratinocytes, with increased expression in older mice, and noted relevant pathway changes that were also evident in human skin, suggesting potential insights into intrinsic skin aging.

In this study, researchers examined chicken feather follicle tissues from differently colored chickens and found that the genes SLC45A2 and GPNMB are involved in promoting melanin deposition, which enriches understanding of the genetic mechanisms affecting feather color.

This research by Yuan et al. focused on developing a comprehensive human skin cell atlas, analyzing various cell types and diseases, and introduced a deep learning method, scSEA, for unbiased reference mapping, potentially discovering new cell types.

The researchers developed a comprehensive human skin cell atlas using data from various studies and established a consensus nomenclature for normal human skin in this project, which also includes a deep learning-based method for more effective reference mapping of new cells.

This study used single-cell RNA sequencing to analyze 26,573 cells from the scapular skin of yaks, identifying 11 major cell types and providing insights into the diversity and morphogenesis of hair follicle cell types through detailed maps of DP cells and dermal fibroblasts.

This study presents a new method called scMC that effectively distinguishes biological from technical variation in single-cell genomics datasets, demonstrating its ability to accurately align and detect biological signals across various experiments.

This study found that Tibetan cashmere goats have genetic adaptations that contribute to their finer cashmere, possibly enhancing their ability to withstand the cold climate of the Tibetan plateau, while identifying specific genes related to hair growth, pigmentation, and heart development.

This study found that maize root hairs respond differently to cold stress based on severity, with mild cold allowing limited growth through adaptive remodeling, while severe cold causes more pronounced inhibition and prioritizes stress defense, affecting transcriptome and morphology.

Changes in genes FGA, VWF, and ACTG1 may contribute to pemphigus vulgaris.

In this study, the researchers analyzed skin samples from Dun Mongolian horses to uncover molecular pathways linked to the "Bider" marking, identifying differential gene expression and several pigment-related signaling pathways that may play key roles in its formation.

This study identified a wide range of differentially expressed lncRNAs and mRNAs in the hair follicles of Hetian sheep, which may be useful for further research on improving carpet wool quality.

This study found a significant association between finasteride use and increased risk of memory impairment, highlighting the need for risk communication and routine cognitive monitoring for long-term users.

This study on male rats found that finasteride treatment led to the differential expression of several genes in the hypothalamus and hippocampus, hinting at potential links to observed side effects like depression, anxiety, and cognitive disturbances.

This study found that overexpression of the FA2H gene in cashmere goats' hair follicle cells may enhance hair proliferation and regulate genes affecting cashmere fineness.

In this study, ceruloplasmin and keratin 4 were identified as markers that differentiate between growing and resting phases in cashmere goat hair follicles, with keratin 4 being a potential marker for the onset of a new hair cycle.

This study identified several previously unrecognized adverse events linked to ISO, including serious conditions such as Dandy-Walker syndrome and suicidal ideation, suggesting that safety measures and drug labeling should be updated.

This review reports that exosome-based therapies, coupled with nanotechnology and AI, show promise in aesthetic medicine, notably in skin rejuvenation and hair restoration, but large-scale trials and clearer regulatory frameworks are needed for effective clinical adoption.

Immune system issues may contribute to female pattern hair loss.

This study found that in a human skin organ culture model of pemphigus vulgaris, split formation led to significant upregulation of IFNγ and TNFα-related genes, indicating secondary effects from mechanical stress, not direct changes from autoantibodies.

This review outlines the evolution and strategies of drug repurposing, highlighting its transformation from accidental discoveries to a predictive, data-driven discipline through the integration of bioinformatics and artificial intelligence, with notable applications during the COVID-19 pandemic.

This review outlines the evolution of drug repurposing from accidental discoveries to a systematic approach enhanced by genomics and data analytics, emphasizing its accelerated relevance during the COVID-19 pandemic and exploring its global and Indian milestones, computational strategies, and future regulatory perspectives.

The research aims to better understand hair follicle regulation and find new treatments for hair loss.

This study observed that specific genes in cashmere goat skin exhibit a seasonal rhythm, potentially adapting to environmental light changes, which may affect downstream gene expression and physiological processes.

Disrupted cell interactions in hair follicles contribute to hair loss in androgenetic alopecia.

This review discusses the immune functions of porcine skin and proposes a classification of dendritic cell subsets based on similarities to human skin, but it reports no new clinical results.

This study highlighted the significance of integrating single-cell RNA sequencing with spatial transcriptomics for improving cell-type identification in human skin, emphasizing the need for a comprehensive cell atlas.

This study provided a dynamic 4D atlas showing the development process of mouse hair follicles through a telescope-like model, revealing new insights into the origin of hair follicle stem cells.

In this study, researchers developed a computational method called iEdgePathDDA that prioritizes anticancer drug candidates by analyzing changes in gene interactions, demonstrating superior performance compared to existing methods across colorectal, breast, and lung cancer datasets.