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    Glossary Post-transcriptional regulation

    control of gene expression after RNA is made from DNA

    Post-transcriptional regulation refers to the control of gene expression after the DNA has been transcribed into RNA but before it is translated into proteins. This process includes modifications like RNA splicing, editing, transport, and stability, which ultimately influence how much protein is produced from a gene. For example, in hair biology, post-transcriptional regulation can affect the production of proteins involved in hair growth and maintenance, potentially impacting conditions like alopecia.

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    1. Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome American journal of human genetics · 2020 · 34 citations
    2. The Transcriptional Regulator Prdm1 Is Essential for the Early Development of the Sensory Whisker Follicle and Is Linked to the Beta-Catenin First Dermal Signal Biomedicines · 2022 · 1 citations
    3. Decision letter: ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas 2015
    4. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation Differentiation · 2009 · 35 citations
    5. Transcriptional regulation of the thymus master regulator <i>Foxn1</i> Science immunology · 2022 · 6 citations
    6. Transcriptional regulation analysis and the potential transcription regulator site in the extended KAP6.1 promoter in sheep Molecular Biology Reports · 2014 · 5 citations
    7. The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1 Journal of Biological Chemistry · 2000 · 119 citations
    8. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    9. WRKY transcription factors (TFs): Molecular switches to regulate drought, temperature, and salinity stresses in plants Frontiers in Plant Science · 2022 · 179 citations
    10. Author response: ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas 2015
    11. NAC transcription factor RD26 is a regulator of root hair morphogenic plasticity bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 1 citations
    12. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis 2024
    13. Mechanisms that regulate androgen receptor transcriptional activity Carolina Digital Repository (University of North Carolina at Chapel Hill) · 2019
    14. A novel <i>MBTPS2</i> variant associated with BRESHECK syndrome impairs sterol‐regulated transcription and the endoplasmic reticulum stress response American Journal of Medical Genetics Part A · 2021 · 5 citations
    15. In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators Nature Cell Biology · 2014 · 173 citations
    16. A computationally inferred regulatory heart aging model including post-transcriptional regulations 2016 · 1 citations
    17. The vitamin D receptor functions as a transcription regulator in the absence of 1,25-dihydroxyvitamin D3 The Journal of Steroid Biochemistry and Molecular Biology · 2015 · 37 citations
    18. In-silico cardiac aging regulatory model including microRNA post-transcriptional regulation Methods · 2017 · 3 citations
    19. Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation Proceedings of the National Academy of Sciences · 2024 · 16 citations
    20. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    21. Pitx2, a β-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro Journal of dermatological science · 2009 · 51 citations
    22. Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor Journal of Ginseng Research · 2015 · 33 citations
    23. 126 cAMP response element-binding protein 1 (CREB) is a β-catenin-regulated transcription factor in squamous cell carcinoma (SCC) cells Journal of Investigative Dermatology · 2018
    24. Lnc056 Enhances Hair Follicle Stem Cells Proliferation by Binding Transcription Factor HNRNPUL1 to Up-Regulate TRIP6 Expression. PubMed · 2025
    25. Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotype Developmental Dynamics · 2000 · 75 citations
    26. Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22 PLOS Genetics · 2015 · 52 citations
    27. RNA Coding and Transcriptional Regulation in Skin Repair: Insights from Single-Cell Profiling and Implications for Organoid-Based Regenerative Strategies Life · 2026
    28. Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation Frontiers in Cell and Developmental Biology · 2026
    29. Deciphering gene regulatory programs in mouse embryonic skin through single-cell multiomics analysis Genome biology · 2025
    30. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing Cell stem cell · 2020 · 128 citations