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Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

No treatment fully prevents hair loss from chemotherapy yet.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Melanocytes are crucial for skin pigmentation and can affect conditions like melanoma, vitiligo, and albinism, as well as hair color and hearing.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Some treatments, like corticosteroids and sensitizing agents, can help with alopecia areata, but more high-quality research is needed.

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Tiny needles with valproic acid can effectively regrow hair.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.

Lamins are vital for cell survival, organ development, and preventing premature aging.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

Sunlight worsens hair loss; protect scalp.

RTA 408 cream protects mice from radiation skin damage.

A position effect on the TRPS1 gene causes excessive hair growth in humans and mice.