research Characterization And Neural Differentiation In Vitro Of Stem Cells From Human Deciduous Tooth Pulp
Dental pulp stem cells might not reliably become neurons.
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research Unlocking the Genetic Secrets of Dorper Sheep: Insights Into Wool Shedding and Hair Follicle Development
This study explores the genetic mechanisms behind wool shedding and hair follicle development in Dorper sheep, known for their natural wool shedding. Researchers conducted transcriptome analysis on skin tissues from adult Dorper ewes, identifying thousands of differentially expressed transcripts and key signaling pathways such as Rap1, estrogen, PI3K-Akt, and MAPK involved in hair follicle development. Core genes like DBI, FZD3, KRT17, ZDHHC21, TMEM79, and HOXC13 were found to be influential. The study also highlights the role of alternative splicing, particularly the isoforms of ZDHHC21, in hair follicle development. These findings provide insights into the genetic basis of hair follicle development in sheep and have potential implications for understanding human hair growth.
research The Relationship Between Keratin 18 and Epithelial-Derived Tumors: As a Diagnostic Marker, Prognostic Marker, and Its Role in Tumorigenesis
Keratin 18 helps diagnose and predict cancer progression and affects cancer growth and spread.
research Plant Elicitor Peptides Regulate Root Hair Development in Arabidopsis
Peps help Arabidopsis plants grow more root hairs by affecting specific genes and calcium signaling.
research Signaling Pathways and Targeted Therapeutic Strategies for Polycystic Ovary Syndrome
Effective PCOS treatments require targeting specific signaling pathways.
research A Human Prenatal Skin Cell Atlas Reveals Immune Cell Regulation of Skin Morphogenesis
Immune cells are essential for early hair and skin development and healing.
research Biomedical Engineering Approaches for the Delivery of JAGGED1 as a Potential Tissue Regenerative Therapy
JAGGED1 could help regenerate tissues for bone loss and heart damage if delivered correctly.
research MiR-23b and MiR-133 Cotarget TGFβ2/NOTCH1 in Dermal Fibroblasts and Affect Hair Follicle Development in Sheep
Two microRNAs affect hair follicle development in sheep by targeting specific genes.
research MicroRNA-205 Promotes Hair Regeneration by Modulating Mechanical Properties of Hair Follicle Stem Cells
MicroRNA-205 helps hair grow by changing the stiffness and contraction of hair follicle cells.
research New Challenge to Cancer and Longevity
A group has developed therapies that show promise for treating cancer and various other conditions.
research The Profibrogenic Role of Neutrophil Extracellular Traps in Stenotic Crohn's Disease: A New Antifibrotic Target?
Targeting NETs may help reduce fibrosis in Crohn's disease.
research Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus
Melatonin affects certain genes and pathways involved in cashmere goat hair growth.
research Clinical and Molecular Genetic Studies in Hereditary Hair Loss
Researchers found a genetic link for hereditary hair loss but need more analysis to identify the exact gene.
research Genome Scan for Signatures of Adaptive Evolution in Wild African Goat (Capra Nubiana)
Wild African goats have genetic adaptations for surviving harsh desert conditions.
research Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus
Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.
research Downstream Molecular Responses to Volatile Signaling in Roots
Plant roots respond to fungus smells by possibly using certain proteins and a plant hormone to change root growth, but more research is needed.
research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)
The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.
research Dermal Niche Signaling and Epidermal Stem Cells
Skin health and repair depend on the signals between skin stem cells and their surrounding cells.
research Effects of Altering Allopregnanolone Levels During Critical Neurodevelopmental Periods on Alcohol Consumption Vulnerability
Early NAS level changes affect alcohol consumption vulnerability.
research Stem Cells in the Body
Stem cells regenerate tissues and their behavior varies by environment, suggesting the hematopoietic system model may need revision.
research Stem Cells in the Skin
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
research Abstracts from the ASA 40th Annual Meeting
HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.
research Hair Today
The document concludes that understanding hair biology is key to treating hair disorders, with gene therapy showing potential as a future treatment.
research Logic-Based Modeling and Drug Repurposing for the Prediction of Novel Therapeutic Targets and Combination Regimens Against E2F1-Driven Melanoma Progression
Tadalafil and Finasteride may help treat aggressive melanoma.
research Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties
Wounded skin cells can revert to stem cells and help heal.
research Visualizing Androgen Receptor Activity in Male and Female Mice
Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.
research CXXC5: A Novel Regulator and Coordinator of TGF-β, BMP, and Wnt Signaling
CXXC5 is a protein that controls cell growth and healing processes, and changes in its activity can lead to diseases like cancer and hair loss.
research Novel Insights Into the Molecular Mechanisms Underlying Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes
Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.
research Remodeling of Root Growth Under Combined Arsenic and Hypoxia Stress Is Linked to Nutrient Deprivation
Combined arsenic and low oxygen stress alters root growth to help plants absorb nutrients.
research EZH2-Mediated Inhibition of MicroRNA-22 Promotes Differentiation of Hair Follicle Stem Cells by Elevating STK40 Expression
The protein EZH2 blocks microRNA-22, increasing STK40 protein, which helps hair follicle stem cells change and grow hair.