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Certain gene variations and irregular X chromosome activity may contribute to hair loss in women who can have children.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

Targeted anticancer therapies can cause severe side effects similar to traditional chemotherapy, but with different types.

Vitamin D is important for bones, hair, blood pressure, and breast development.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Hair growth and development are controlled by specific signaling pathways.

Two rare genetic diseases cause severe rickets in children due to defects in vitamin D metabolism.

Mice without the vitamin D receptor are more prone to UV-induced skin tumors.

Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.

Hyaluronate fragments can help reverse skin thinning by working with the CD44 receptor.

Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.

Skin cells called dermal fibroblasts are important for skin growth, hair growth, and wound healing.

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

Wnt signaling is crucial for skin development and hair growth.

Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

Targeting TGFβ can improve skin immunity in older people.

Vitamin D3 is important for bone health and may help treat various diseases beyond bone-related conditions.

Overexpressing thrombospondin-1 in mice skin prevents UVB-induced skin damage.

Topical retinoids effectively improve photodamaged skin.

Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.

Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.

Different types of stem cells help maintain and heal skin.

SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.

17β-estradiol can reduce inflammation in the skin.

Vitamin D receptor may help protect against UV-induced skin cancer.

RXRα is crucial for proper immune response and links diet to immune function.