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This review discusses the challenges and contradictions in understanding nanoparticle penetration and toxicity in human skin, emphasizing the need for standardized testing and further research on particles smaller than 10 nm.

This review introduces pharmacophore technology and discusses its applications in toxicity prediction and limits, but reports no new clinical results.

This review highlights the potential for physical exercise to reduce treatment toxicity and modification rates in patients with metastatic colorectal cancer receiving systemic treatments, suggesting benefits for survival outcomes; it recommends further trials to confirm these findings.

This article reviews the potential neuroprotective effects of 17α‐estradiol in neurodegenerative diseases and highlights its possibly lower toxicity compared to more feminizing hormones, but it reports no new clinical findings.

This article reviews the use of sodium fluoride in otosclerosis management, finding limited evidence of its efficacy in preventing hearing deterioration and highlighting potential toxicity concerns.

In this study, combining pemetrexed with cisplatin in non-small cell lung cancer patients improved immune function and had lower blood toxicity compared to cisplatin with gemcitabine, despite similar disease control rates and other side effects between the two treatment groups.

This review discusses preclinical and clinical chemoprevention research for several cancers, noting challenges in effectiveness and toxicity, and emphasizes the need for further trials.

This review discusses the properties and therapeutic potentials of beta-sitosterol, highlighting a need for more detailed studies on its mechanisms and long-term effects in humans; it reports no new results.

This review explores research on nanoformulations for enhancing the topical delivery of herbal medicines, noting potential benefits like improved bioavailability and sustained delivery, and emphasizes the need for safety and toxicity guidelines in developing these novel drug delivery systems.

This review discusses the pharmacological actions and potential therapeutic benefits of ginsenoside compound K for metabolic disorders, reports no new clinical results, and suggests further research on its bioavailability and toxicity.

This review found that Hibiscus rosa sinensis extracts exhibit diverse medicinal properties, such as anti-inflammatory and antioxidant effects, with minimal toxicity at high doses, though some altered blood markers, indicating a need for further research into their mechanisms and clinical applications.

This review highlights the medicinal potential of Acorus calamus, identifying its bioactive components and demonstrating its pharmacological activities, but also notes the need for more research on toxicity and safety.

This opinion article explores the possibility of repurposing anticancer drugs, like methotrexate, as antimalarials, highlighting that toxicity might be manageable with appropriate dosing according to Paracelsus' law.

This review discusses the traditional uses and biological activities of Aristotelia chilensis, summarizing its phytochemical composition and various potential health benefits, but reports no original research findings and highlights the need for further studies.

This study found that using a combination of Alginate-TEMPO-oxidized cellulose nanofiber-α-tocopherol membranes and Pluronic-α-tocopherol hydrogels facilitated better wound healing in diabetic rats through enhanced angiogenesis and no observable toxicity compared to using each treatment individually.

This abstract discusses the efficacy of spironolactone, cyproterone acetate, and flutamide in treating female pattern hair loss, noting that flutamide use requires caution due to potential liver toxicity, especially at high doses.

In this study, researchers developed a multifunctional, injectable hydrogel that adapts to irregularly shaped wounds, enhances healing, and shows potential antibacterial activity without significant toxicity, suggesting promise for treating chronic wounds.

This paper reviews total skin electron therapy for mycosis fungoides and reports no new results; the authors focus on dose de-escalation's impact on toxicity and response rates.

This review assesses the potential of dutasteride as a promising treatment for ALS due to its reported neuroprotective, antioxidant, and anti-inflammatory effects, but emphasizes that clinical studies are needed for confirmation.

In this study, researchers developed a mucoadhesive hydrogel ovule containing retinyl palmitate and curcumin for intravaginal use, showing controlled drug release, selectivity against cancerous HeLa cells, and non-toxicity to healthy cells, which may offer a potential treatment for cervical cancer.

This review discusses the diverse therapeutic properties of Hibiscus rosa sinensis, including anti-inflammatory and anti-cancer effects, and notes that while most extracts showed no toxicity, some altered biological markers, necessitating further research to explore its medicinal potential through clinical trials.

This study found that cis-urocanic acid can engage in non-enzymatic reactions with reactive sulphur species, forming new metabolites, and suggests sulphide donors may protect against UVB-related toxicity.

This review highlights Croton tiglium's dual therapeutic and toxic properties, noting its potential for hair growth promotion through PKC-mediated pathways, while emphasizing the challenges posed by its toxicity for safe clinical use.

This review highlights the significant antidiabetic activity of Allium ascalonicum (shallot), attributed to its flavonoid compounds like quercetin, in reducing blood glucose levels across various studies, while calling for further research to confirm its safety and efficacy as a diabetes treatment.

This comprehensive review reports on the therapeutic potential and bioactive components of licorice (Glycyrrhiza glabra Linn), highlighting its diverse pharmacological properties and health benefits but also noting associated toxicity and adverse effects in medicinal and food applications.

This review outlines the therapeutic uses and phytochemical composition of Hibiscus rosa sinensis, highlighting its potential anti-inflammatory, anti-cancer, and other benefits, but it also calls for more research due to observed changes in hematological and biochemical markers in toxicity tests.

In this study, researchers identified specific clinical and dermoscopic features of chronic radiation-induced dermatitis in 32 head and neck cancer patients treated with radiotherapy, and determined age, gender, and prior surgery as independent risk factors for developing this skin toxicity.

This review evaluates traditional uses, phytochemical profiles, and pharmacological activities of Mediterranean Erica species, revealing the wide range of bioactive compounds and highlighting their antioxidant, anti-inflammatory, and antimicrobial activities. Further studies are suggested to fully understand their medicinal potential.

New retinoids are effective for various skin conditions and are being developed to have fewer side effects.

This study found that metformin did not prevent gentamicin-induced hearing loss and even worsened auditory threshold shifts and caused adverse effects at higher doses in guinea pigs.