1 citations
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October 2021 in “Al-Rafidain journal of medical sciences.” This review discusses the toxic effects and mechanisms of platinum compounds in cancer treatment, emphasizing the need for new compounds with different mechanisms of action; it reports no new clinical results.
179 citations
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October 2018 in “American Journal of Clinical Dermatology” This review outlines various dermatologic adverse events associated with targeted therapies and immunotherapies, emphasizing the need for collaboration between dermatologists and oncologists to manage these effects effectively; it reports no new clinical findings.
This study found that Botox® was most effective at a 25 U/ml concentration, while Dysport® and Neurobloc® were optimal at 100 U/ml for producing anhidrotic areas after injections.
17 citations
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August 2014 in “Journal of Craniofacial Surgery” In this study on rats, botulinum toxin–A injection was reported to reduce contraction in wounds and skin grafts, with changes in inflammation and collagen arrangement also observed.
15 citations
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April 2020 in “Journal of The American Academy of Dermatology” In this study, intradermal injection of botulinum toxin was associated with increased hair growth in men with androgenetic alopecia through the suppression of TGF-β1 secretion from dermal papilla cells.
3 citations
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January 2022 in “Neurotoxicity Research” This study found that botulinum toxin type A injections in stressed mice appeared to normalize hair follicle regeneration cycles and reduced stress-related hair loss indicators.
January 2026 in “International Journal of Applied Pharmaceutics” This study found that a hair tonic containing 10% mesenchymal stem cell secretome significantly increased hair density in volunteers with alopecia after eight weeks, suggesting its potential as an effective treatment option for hair growth stimulation.
March 2025 in “Journal of Cosmetic Dermatology” The study found that botulinum toxin-A significantly increased the diameter of the supratrochlear artery in a small patient group, suggesting potential vasodilatory benefits for treating ischemic conditions.
December 2025 in “Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)” In this review, researchers examined nine studies on botulinum toxin type A's effects on biomarkers in chronic head and neck conditions, finding significant, though low to moderate certainty, changes in markers like CGRP and serotonin associated with inflammation and mood disorders.
15 citations
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January 2020 in “BioMed Research International” In this study of patients with androgenetic alopecia, botulinum toxin type A was found to significantly increase hair counts and improve hair density and coverage, with enhanced results observed when combined with oral finasteride, revealing a safe and effective treatment approach without adverse effects.
October 2022 in “Our Dermatology Online” In this study, researchers compared the effectiveness of a tonic containing Capixyl, Procapil, and rosemary extract with 2% minoxidil in reducing hair loss and promoting hair growth in male participants over a 24-week period.
24 citations
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December 2010 in “Dermatologic surgery” In this study, BTXA injections did not effectively treat recalcitrant alopecia areata or improve hair regrowth in most patients, suggesting its limitations as an alternative therapy.
2 citations
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January 2011 in “The Korea Journal of Herbology” In this study, the herbal hair tonic and natural food treatment in C57BL/6 mice were associated with increased hair density and thickness compared to controls, suggesting potential hair growth benefits.
1 citations
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April 2012 in “Korean Journal of Food Science and Technology” This study found that combining an oral herbal composition with a topical hair tonic resulted in a stronger hair growth effect in mice than either treatment alone.
1 citations
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May 2008 in “Toxicon” This study found that BOTOX doses of 75–100 U effectively reduce postvoiding residual urine and detrusor pressure in patients with detrusor sphincter dyssynergia.
June 2026 in “Dermatology and Therapy” In this retrospective analysis, patients with trichodynia who were unresponsive to standard treatments showed significant symptom improvement after receiving intradermal botulinum toxin type A, with nearly all patients benefiting, particularly those with scarring alopecia.
January 2025 in “Dermatologic Surgery” This meta-analysis and systematic review found that botulinum toxin injections significantly increased hair count in patients with androgenetic alopecia compared to controls, indicating promising efficacy and good safety.
This study found that subcutaneous administration of Botulinum toxin type A significantly reduced histamine-induced itch intensity and neurogenic inflammation in human skin compared to saline.
February 2024 in “International Journal of Health and Pharmaceutical” In this study, Avemor, a tonic containing aloe vera and moringa oleifera, along with varying concentrations of dried moringa leaf extracts, was tested on rabbits for hair growth, but the results showed variable effectiveness compared to a minoxidil control.
44 citations
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October 2017 in “British Journal of Dermatology” This review discusses the broadening scope of botulinum toxin applications beyond traditional uses, highlighting its effects on non-neuronal cells and potential in treating various dermatological conditions, without reporting new clinical findings.
13 citations
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May 2020 in “Journal of Plastic Reconstructive and Aesthetic Surgery” This systematic review found inconclusive evidence on the effectiveness of botulinum toxin for treating alopecia and highlighted the need for further prospective randomized controlled trials.
June 2025 in “Fayoum University Medical Journal/Fayoum University Medical Journal ” This study found that both intralesional minoxidil 8% and botulinum toxin type A were equally effective in treating female pattern hair loss, with no significant difference in results between the two treatments.
12 citations
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December 2018 in “Dermatologic Therapy” Small Botox dose effectively treats hair loss in Chinese men.
24 citations
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January 2017 in “Journal of Cutaneous and Aesthetic Surgery” In this pilot study, botulinum toxin was found to be a safe and effective treatment for androgenetic alopecia in most participants, though larger studies are needed to confirm these findings.
1 citations
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July 2020 in “Journal of The American Academy of Dermatology” This review discusses the potential mechanisms by which intradermal botulinum toxin may affect androgenetic alopecia but notes that high-evidence clinical trials have yet to show conclusive results.
12 citations
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August 2015 in “Plastic Surgery” This study found that botulinum toxin type A significantly reduced skin flap necrosis in rats exposed to cigarette smoke, suggesting it may help improve flap viability in smokers.
2 citations
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November 2024 in “Aesthetic Surgery Journal” This study found that vibration anesthesia significantly reduced pain during botulinum toxin injections for masseter reduction without affecting the injection's diffusion or causing adverse effects, and high patient satisfaction was also reported.
March 2024 in “Journal of Society of Cosmetic Chemists of Japan” In this study, a medicated hair growth tonic containing RJ extract increased hair counts, the proportion of anagen phase hairs, and scalp moisture in human trials, although the specific role of RJ in hair growth remains unclear due to other active ingredients.
December 2023 in “JSFK (Jurnal Sains Farmasi Klinis)/JSFK (Jurnal Sains Farmasi dan Klinis)” This study found that a hair tonic formulated with 0.3% cocoa bean extract demonstrated the best physical stability and effectively promoted hair growth in mice, with results comparable to a positive control when used twice daily for two weeks.
January 2023 in “The Egyptian Journal of Hospital Medicine” This study found that type A botulinum toxin treatment significantly increased hair thickness and reduced vellous hair count in patients with androgenetic alopecia, suggesting its potential as an effective therapy.