13 citations
,
August 2018 in “Clinical Chemistry” This study determined that a total testosterone concentration of ≥5.1 nmol/L identified androgen-producing tumors in women with severe hyperandrogenemia, while a lower threshold of ≥2.2 nmol/L was found for diagnosing pathologic hyperandrogenism in postmenopausal women.
9 citations
,
February 2020 in “International Journal of Endocrinology” This study found that men with early-onset androgenetic alopecia and certain risk factors may have worse gonadal steroidogenesis and an increased likelihood of developing gonadal dysfunction, suggesting a male equivalent of polycystic ovarian syndrome.
9 citations
,
January 2017 in “Ginekologia Polska” This study found that the total testosterone/dihydrotestosterone ratio correlates with a negative metabolic profile in both women with PCOS and healthy women.
November 2025 in “BMC Endocrine Disorders” This study found that in PCOS patients, a lower TT/DHT ratio is associated with regular menstruation, while higher ratios are linked to insulin resistance, suggesting its potential as a biomarker for metabolic severity in these patients.
January 2001 in “대한피부과학회지” This study found no significant differences in plasma DHEA-S and total testosterone levels between female patients with androgenetic alopecia and normal controls, regardless of clinical type or hyperandrogenic symptoms.
January 1995 in “대한피부과학회지” This study found that women with androgenetic alopecia had significantly higher mean plasma levels of DHEA-S and total testosterone compared to normal females, despite most individuals in both groups being within normal hormonal ranges.
November 2023 in “PubMed” This study found significant gender differences in total testosterone and dehydroepiandrosterone sulfate levels among noncritical COVID-19 patients, which were associated with severity markers in males.
3 citations
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January 2018 in “Frontiers in bioscience” This retrospective analysis reported significant increases in testosterone levels in men with testosterone deficiency using the Daily Subcutaneous Testosterone method combined with hCG and anastrozole, indicating its potential as a treatment option.
November 2022 in “Journal of the Endocrine Society” This case study highlights the complexity of managing PCOS and its symptoms in transmen, suggesting hormonal fluctuations may lead to symptomatic relief with low dose estradiol.
November 2022 in “Journal of the Endocrine Society” In this case study, biotin supplementation was reported to interfere with free testosterone assay results, leading to falsely low readings in a postmenopausal woman with hyperandrogenism.
November 2021 in “Research Outreach” Low testosterone levels may lead to more severe COVID-19 outcomes.
6 citations
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May 2016 in “Urolithiasis” This study found that the risk of urinary stone disease increased significantly in patients with severe androgenetic alopecia, and that testosterone deficiency was more frequent among these patients.
17 citations
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February 2019 in “Journal of Clinical Medicine” This article reviews guidelines for testosterone replacement therapy in late-onset hypogonadism, emphasizing the need for clear indications and appropriate testing before treatment, but provides no new research findings.
October 2023 in “Journal of the Endocrine Society” In this case report, a post-menopausal woman with symptoms such as hirsutism and elevated testosterone underwent surgery, which revealed hormonally active ovarian cellular fibromas, leading to symptom resolution and normalized hormone levels; the authors suggest further exploration of these tumors' hormonal effects.
May 2024 in “Journal of drug delivery and therapeutics” This study found that women with polycystic ovarian syndrome at a gynecology clinic in Nnewi exhibited significant oxidative stress and hormonal imbalances compared to controls.
June 2022 in “Journal of Experimental Biology and Agricultural Sciences” This study found that steroid hormones influence the quality indicators of fresh and cryopreserved stallion sperm, with testosterone negatively correlated with motility and estradiol positively correlated with survival rate.
May 2026 in “Global Translational Medicine” This study found that ethanol extract of Syzygium aromaticum (clove) leaves significantly improved lipid profiles and increased body weight in testosterone-induced benign prostatic hyperplasia rats, suggesting potential anti-hyperlipidemic effects and modulation of body weight through metabolic activity.
166 citations
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March 2007 in “Hypertension” In this study, hyperandrogenemia in young women with polycystic ovary syndrome was linked to higher blood pressure, independent of factors like age, insulin resistance, obesity, or dyslipidemia.
120 citations
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June 2008 in “American Journal of Epidemiology” This study reported a 6.3% prevalence of PCOS among women in a Sri Lankan community, with most cases presenting as oligo/amenorrhea and polycystic ovaries.
118 citations
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February 2009 in “Fertility and Sterility” This study found that approximately 75% of women with PCOS exhibited hyperandrogenemia, with free testosterone being the most frequently elevated marker.
82 citations
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May 2016 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” This article outlines the clinical features, evaluation, and treatment strategies for androgen excess in polycystic ovary syndrome, highlighting important diagnostic and management approaches but reporting no new research results.
77 citations
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June 2006 in “Best Practice & Research Clinical Endocrinology & Metabolism” This review discusses the importance of androgen production and metabolism in hyperandrogenism, the use of specific serum markers for diagnosis, and the need for improved assays for clinical testing, but reports no new results.
67 citations
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February 2010 in “Acta Obstetricia et Gynecologica Scandinavica” In this study, hirsutism in women with PCOS was strongly associated with hyperandrogenism and metabolic abnormalities, while acne and androgenic alopecia were not effective markers for hyperandrogenism.
66 citations
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November 2001 in “European journal of endocrinology” This study suggests that decreased SHBG levels and increased FAI, free testosterone, and DHEAS concentrations are effective in diagnosing PCOS in epidemiological studies of women of reproductive age.
61 citations
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January 2015 in “Hormones” In this study, short-term liraglutide treatment led to significant weight loss in obese women with newly diagnosed PCOS and a higher metabolic risk profile compared to metformin.
56 citations
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October 2018 in “Journal of The American Academy of Dermatology” This review discusses the role of androgens in women's skin-related conditions like acne, hirsutism, and female pattern hair loss, noting the lack of dermatology guidelines for when to pursue endocrinologic evaluation.
35 citations
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March 2012 in “Experimental and Clinical Endocrinology & Diabetes” This article discusses various causes of hyperandrogenism in women and highlights diagnostic considerations for conditions such as PCOS, NCCAH, Cushing's disease, and androgen-secreting tumors, without reporting new clinical results.
32 citations
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January 1990 in “Clinical Endocrinology” This study found that women with female pattern androgenic alopecia have significantly higher levels of certain androgens and androgen sulfates compared to normal premenopausal women, suggesting markers for diagnosis and treatment efficacy.
18 citations
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January 2015 in “Journal of obesity and weight loss therapy” This study found that an 8-week low-starch/low-dairy diet led to weight loss, improved insulin sensitivity, and reduced testosterone levels in women with PCOS.
18 citations
,
May 1992 in “American Journal of Biological Anthropology” This study found no general elevation in androgen levels among men predisposed to balding, despite a correlation with the free-to-total testosterone ratio; no link was observed with acne.