Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that the zinc transporter ZIP10 is crucial for epidermal development, as it influences the activity of p63, promoting epidermal morphogenesis.

This study describes trichilemmal keratinization as a distinct process of hair follicle keratinization that occurs in specific areas of the outer root sheath, illustrated using electron microscopy on dog hair.

This study found that type 2 immunity may play a role in the development of alopecia areata in patients with extrinsic atopic dermatitis, indicating different immunological states compared to non-atopic patients.

This study proposes a new method to selectively isolate keratin-associated proteins and keratin from human hair, suggesting that KAPs may support keratin fibers in hair structure.

This study identified a mutation hotspot in the caracul (Ca) locus of mice, implicating the mK6irs1/Krt2-6g gene in hair formation and potentially human hair and skin diseases.

This study found that monoclonal antibodies can identify specific immunological characteristics of hair fibrous proteins, with some antibodies reacting only with hair proteins and others showing broader activity with skin and epithelial cells.

This study found that testosterone is converted to estrogenic steroids in vitro without aromatase involvement, suggesting that combining 5α-reductase and aromatase inhibitors might reduce estrogenic steroids more completely in vivo.

This study found that Eda and activin A regulate Foxi3 expression, which may contribute to the development of hypohidrotic ectodermal dysplasia by affecting Foxi3 activity in ectodermal appendages like hair and teeth.

This study found that somatic mosaic mutations in the doublecortin gene may cause subcortical band heterotopia in male patients, and molecular analysis using hair roots is a useful detection method.

This review discusses the genetic, autoinflammatory, and keratinization factors involved in hidradenitis suppurativa and presents the concept of classifying it as an autoinflammatory keratinization disease, but reports no new clinical results.

This study found that among Japanese IBD patients, the NUDT15 p.Arg139Cys variant was significantly associated with thiopurine-induced leukopenia and severe hair loss, suggesting its genotyping is important for predicting these adverse events.

In this study, the researchers identified the specific subcellular localization of the protein S100A3 in the endocuticle and cortex of human hair shafts.

This study found that 50-nm PLGA nanoparticles delivered with iontophoresis enhanced skin permeation of indomethacin in rats more effectively than 100-nm nanoparticles, suggesting improved targeting of hair follicles.

This article reviews the side effects of topical latanoprost therapy, particularly the hypertrichosis and pigmentation changes of eyelashes and nearby skin, and reports no new clinical results.

This study identified and isolated highly proliferative canine keratinocytes in vitro, finding that follicular keratinocytes showed distinct proliferative capacity and marker expression indicative of putative epithelial stem cells.

This study found that PDCD4 protein expression is reduced in various skin cancers compared to normal skin, suggesting its potential role in preventing or treating certain skin cancers.

This article updates Japanese guidelines for diagnosing and treating male and female-pattern hair loss, recommending specific drugs and therapies while advising against certain treatments for female-pattern hair loss.

This case report describes how discontinuing the EGFR inhibitor gefitinib led to rapid improvement of erosive scalp pustules in a woman with non-small-cell lung cancer, despite previous antibiotic and steroid treatment failures.

This study developed a validated murine model of hypertrophic scar contraction, demonstrating similarities to human skin and observing graft contraction and tissue characteristics over time.

This study found that overexpression of sPLA2-X in mice was associated with alopecia and hair follicle abnormalities, highlighting its potential role in hair follicle homeostasis.

This study found that the lack of expression and deletion of specific hair keratin genes on chromosome 7q36 in Hirosaki hairless rats suggests the crucial role of these genes in hair growth.

This study found that minoxidil increased 17ß-hydroxysteroid dehydrogenase activity by nearly 40% in dermal papilla cells from balding scalps but not in nonbalding scalp cells or dermal fibroblasts.

This review discusses advances in understanding epidermal biology and pathology over the past two decades and highlights the significant progress yet acknowledges that much remains to be discovered; no new clinical results are reported.

This study reports that in ovarian high-grade serous carcinoma, overexpressed S100A4 likely promotes epithelial-mesenchymal transition and cancer stem cell properties, affecting tumor behavior through its interaction with NMIIA and mutant p53.

In this study, VD(3) pretreatment increased hair follicle formation in a rat model by promoting dermal papilla cell differentiation, suggesting potential for hair regeneration therapy.

This study found that OPC-17116 can be reliably detected in hair, suggesting it can serve as an index of drug exposure and a time-marker in hair analysis.

This study found that expression of certain mutant keratin genes in mice led to severe alopecia, suggesting a similar mechanism could cause hair loss in humans.

This report documents a novel alanine to valine substitution in the GJB2 gene in a Japanese girl with severe keratitis–ichthyosis–deafness syndrome, suggesting a potential link to her severe recurrent infections and immunodeficiency.

This study found that an 11-month-old Japanese infant developed biotin deficiency while on a Japanese amino acid formula without biotin, which was resolved with biotin supplementation.