October 2023 in “Pharmacoepidemiology and Drug Safety” This study found that in Denmark, dermatology drugs are mostly used as expected, but identified a few unexpected patterns that warrant targeted follow-up to determine if there is inappropriate use.
74 citations
,
July 1991 in “The Journal of Urology” This study found that topically applied minoxidil was more effective than nitroglycerin and placebo in enhancing penile diameter, rigidity, and arterial flow, with the most pronounced effects in patients with neurogenic impotence.
3 citations
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July 2013 in “Bioscience, Biotechnology, and Biochemistry” This study found that topically applied Chinese black tea extract, when fermented and combined with capsaicin, significantly promoted hair growth in mice, potentially involving estrogen receptor interactions.
January 2026 in “International Journal of Molecular Sciences” This review suggests that topically applied peptides may offer a promising alternative for managing pain in chronic wounds, with additional potential benefits of anti-inflammatory and regenerative activities, but acknowledges the challenges of delivering these peptides across damaged skin barriers.
77 citations
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January 1993 in “Skin Pharmacology and Physiology” In this study, topically applied glucocorticosteroids were found to block hair growth at the stage of hair formation, but not the initiation of hair growth, in a mouse model.
145 citations
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November 2017 in “Journal of The European Academy of Dermatology and Venereology” This guideline review by the European Dermatology Forum evaluates current treatments for androgenetic alopecia but reports no new research findings, aiming to assist dermatologists in selecting safe and effective therapies.
127 citations
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June 2006 in “International Journal of Pharmaceutics” This research found that liquid-state liposomes and niosomes may enhance finasteride delivery to pilosebaceous units in hamsters more effectively than gel-state vesicles or hydroalcoholic solution.
39 citations
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July 2016 in “Biomedicine & Pharmacotherapy” In this animal study, researchers found that cedrol, a constituent from Platycladus orientalis, significantly promoted hair growth in a dose-dependent manner in female C57BL/6 mice, surpassing results from blank control and 2% minoxidil groups over 21 days.
5 citations
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May 2020 in “Pharmaceutical Research” This study found that short durations of heat and specific chemical penetration enhancers significantly improved the delivery of finasteride to human scalp skin and hair follicles.
1 citations
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September 2002 in “PubMed” This study found that using a topical 2% minoxidil solution for 6-12 months may reduce hair loss and improve hair root conditions in some women with androgenic alopecia.
May 2017 in “Journal of The American Academy of Dermatology” This phase 2 trial found that SM04554, a Wnt signaling modulator, was well-tolerated and increased follicle counts in males with androgenetic alopecia, suggesting potential for promoting hair growth.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Quantitative Mass Spectrometry Imaging offers precise localization and quantification of active compounds in skin tissues, demonstrating benefits over traditional LC-MS in drug penetration studies.
January 2023 in “International Journal of Trichology” In a case series, this study reported significant hair regrowth in both men and women with androgenetic alopecia using a topical hemp extract high in CBD, THCV, and CBDV over six months.
2 citations
,
April 2019 in “Pharmaceutical sciences and research” This study found that lotion containing ethanolic extract of Phyllanthus niruri promoted hair growth in rats, with the addition of 1% menthol enhancing this effect compared to the extract alone.
2 citations
,
January 2011 This study found that topical 5% aqueous extract of Trichosanthes dioica R. leaves significantly promoted hair growth in rats compared to both a control and minoxidil treatment.
1 citations
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March 2024 in “International Journal of Pharmaceutical Sciences and Drug Research” In this study on albino mice, Helianthus annuus and Martynia annua seed oil extracts in petroleum ether significantly promoted hair growth in a dosage-dependent manner, with 30 mg/ml showing notable results compared to 2% minoxidil.
1 citations
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January 2023 in “Research Square (Research Square)” This study found that a neem-based herbal formulation may be more effective than ivermectin in treating sarcoptic mange in dromedary camels, leading to complete recovery without scarring or keratinization.
January 2026 in “Plastic & Reconstructive Surgery Global Open” This study reported that applying stem cell serum daily resulted in eyebrow hair regrowth in a patient with chronic secondary cicatricial alopecia, and prevented hair loss in another patient with acute eyebrow trauma, suggesting it as a noninvasive treatment alternative.
July 2024 in “Journal of Cosmetic Dermatology” This study on rats found that topical application of bacterial melanin significantly stimulates hair growth by prolonging the anagen phase and enhancing vasodilation in the treated skin areas compared to controls, suggesting its potential as a cost-effective hair growth treatment.
January 2005 in “Nihon Yasei Doubutsu Igakkaishi/Japanese journal of zoo and wildlife medicine” This study observed that Aloe vera gel applied topically to mange-affected camels led to the rapid disappearance of skin lesions and mites.
30 citations
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December 1972 in “Archives of dermatology” This report examines efforts to enhance the efficacy of topical steroids for alopecia areata using penetration-enhancing vehicles and exceptionally high concentrations, noting systemic steroids often lead to relapses and toxicity.
10 citations
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January 1996 in “Journal of Dermatological Treatment” In this study, a standardized 7.5% herbal extract significantly increased hair growth in men with androgenetic alopecia compared to a placebo over a 48-week period.
1 citations
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September 2021 in “Frontiers in Endocrinology” This case report describes the use of topical minoxidil to successfully promote facial hair growth in a 17-year-old trans male unable to start testosterone therapy, with skin dryness as the only reported side effect.
3 citations
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February 1990 in “Contact Dermatitis” Contact dermatitis may speed up hair loss in some cases.
This study reports that topical 5% minoxidil solution significantly increased total hair counts and hair diameter in Korean men with androgenetic alopecia over 24 weeks and was well tolerated.
26 citations
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March 2007 in “Clinical and experimental dermatology” Pimecrolimus cream is not effective for treating alopecia areata.
18 citations
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October 2015 in “Journal of the European Academy of Dermatology and Venereology” In this study, topical eflornithine reduced hair regrowth in hirsute patients following intense pulsed light therapy, suggesting it may maintain IPL-induced hair reduction over six months.
4 citations
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January 2017 in “Indian Dermatology Online Journal” This case study describes severe hypertrichosis in a 3-year-old with alopecia areata after unsupervised use of high-dose topical minoxidil, highlighting the need to avoid such practices in children.
March 2025 in “Formosa Journal of Sustainable Research” In this study involving male mice, Mangkokan leaf extract (Polyscias scutellaria) at a 7% concentration was found to heal incision wounds faster compared to 3% and 5% concentrations.
September 2024 in “Journal of the American Academy of Dermatology” In this prospective, placebo-controlled study, the researchers observed a significant reduction in hair shedding in women after applying the combined topical treatment DA-OTC-002, containing synephrine and TAAR agonists, compared to placebo, showing a 62.5% average reduction with no reported adverse events.